{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent study (1) investigating tricuspid regurgitation (TR)–induced right ventricular cardiomyopathy, INTS6‐AS1 was identified as a differentially expressed long non‐coding RNA that participates in a competitive endogenous RNA (ceRNA) network. Specifically, INTS6‐AS1 is predicted to interact with hsa‐miR‐4262 to modulate the expression of NEURL1B, suggesting that through miRNA sponging, it may help regulate signaling pathways associated with cardiac remodeling and inflammation in the diseased myocardium. The study’s integrative analyses of mRNA, miRNA, and lncRNA expression profiles, combined with immune infiltration assessments, underscore the potential of INTS6‐AS1 as a novel therapeutic target that could influence the progression of TR‐induced cardiomyopathy."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chengnan Tian, Yanchen Yang, Yingjie Ke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative Analyses of Genes Associated With Right Ventricular Cardiomyopathy Induced by Tricuspid Regurgitation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.708275"}], "href": "https://doi.org/10.3389/fgene.2021.708275"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34603374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34603374"}]}]}]}