{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the provided abstracts specifically mention IQCH‐AS1, the collective insights from these studies underscore key roles for long non‐coding RNAs (lncRNAs) in disease development and prognosis. For example, one study demonstrating an individualized approach to differential lncRNA expression in lung adenocarcinoma showed that disruptions in the normal ordering of lncRNA expression can be harnessed to build prognostic signatures that reliably stratify patients (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In another investigation focused on severe burn injuries, lncRNAs were integrated into miRNA–mRNA regulatory networks, suggesting that such molecules can modulate critical cellular pathways including ribosome biogenesis and MAPK signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, a study in multiple myeloma identified a lincRNA signature that independently predicted progression-free and overall survival, further highlighting the potential clinical impact of deregulated lncRNA expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n By extrapolating from these findings, IQCH‐AS1—a long non‐coding RNA—could be hypothesized to exert similar functional influences. It may participate in the deregulation of gene expression networks in disease contexts, potentially affecting cell proliferation, stress response, or other pathways involved in oncogenesis or tissue repair. However, targeted investigations are required to clarify its precise molecular mechanisms and its impact on disease initiation and progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fuduan Peng, Ruiping Wang, Yuanyuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-017-0666-z"}], "href": "https://doi.org/10.1186/s12943-017-0666-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28587642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28587642"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gongjie Tang, Tao Zhang, Xinbo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sub-pathway analysis for severe burns injury patients: Identification of potential key lncRNAs by analyzing lncRNA-mRNA profile."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2018.6089"}], "href": "https://doi.org/10.3892/etm.2018.6089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29805546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29805546"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mehmet Kemal Samur, Stephane Minvielle, Annamaria Gulla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-018-0116-y"}], "href": "https://doi.org/10.1038/s41375-018-0116-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29749396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29749396"}]}]}]}