IQGAP1 Gene

Name	IQ motif containing GTPase activating protein 1
Description	This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n IQGAP1 is a highly versatile scaffold protein that integrates multiple signaling pathways with the regulation of cytoskeletal dynamics, thereby orchestrating diverse cellular processes. For example, IQGAP1 contributes to successful cytokinesis by associating with proteins involved in midbody abscission during cell division"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and regulates cell polarization by interacting with microtubule‐binding proteins such as CLIP-170 and the small GTPases Rac1 and Cdc42 at the leading edge of motile cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, IQGAP1 functions as a key effector in the Ras/mitogen-activated protein kinase pathway by binding directly to MEK, ERK, and B-Raf to modulate growth factor–stimulated signaling"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "; this modulation is central to cell proliferation and differentiation. Moreover, IQGAP1 promotes cell migration and invasion by coordinating actin reorganization and invadopodia formation—actions that are mediated by its interactions with Rac1/Cdc42 as well as with exocyst complex components, thereby directing matrix proteolysis in invasive tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In endothelial cells, IQGAP1 acts as a scaffold that couples activated vascular endothelial growth factor receptor-2 (VEGFR2) with Rac1 and other signaling components to coordinate reactive oxygen species production and cell migration during angiogenesis and vascular repair"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and has also been implicated in linking NAD(P)H oxidase (Nox2) to cortical actin at the leading edge."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " IQGAP1 additionally contributes to phagocytic cup formation by recruiting the actin nucleator Dia1 to defined subcellular locations following RhoA activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In the context of tumorigenesis, aberrant IQGAP1 expression has been correlated with enhanced invasive and proliferative capacities in hepatocellular and breast carcinomas"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": "; in some cases, its overexpression is linked to deregulated cell–cell adhesion and altered β–catenin signaling. At the molecular level, the actin-binding capacity of IQGAP1 is modulated by Ca²⁺/calmodulin, which binds to its IQ motifs under elevated calcium conditions and thereby reversibly attenuates its association with cortical F–actin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In epithelial cells, IQGAP1 further facilitates the stability of cell–cell junctions by modulating the local activity of Rac1, thus reinforcing the actin meshwork that supports E–cadherin–mediated adhesion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Finally, IQGAP1 is found in complexes with mRNA–binding proteins in neuronal cells, suggesting a role in mRNA localization and regulated translation during neuronal development"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", and its interaction with other factors may be influenced by oncogenic or metabolic cues such as bile acids"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "and INF2 mutations that perturb its binding interfaces."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Collectively, these findings underscore IQGAP1’s multifaceted role as an integrator of signaling and cytoskeletal architecture that is essential for dynamic cellular behaviors in both normal physiology and disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Eiji Morita, Virginie Sandrin, Hyo-Young Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601850"}], "href": "https://doi.org/10.1038/sj.emboj.7601850"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17853893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17853893"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Masaki Fukata, Takashi Watanabe, Jun Noritake, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(02)00800-0"}], "href": "https://doi.org/10.1016/s0092-8674(02"}, {"type": "t", "text": "00800-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12110184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12110184"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Monideepa Roy, Zhigang Li, David B Sacks "}, {"type": "b", "children": [{"type": "t", "text": "IQGAP1 is a scaffold for mitogen-activated protein kinase signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.18.7940-7952.2005"}], "href": "https://doi.org/10.1128/MCB.25.18.7940-7952.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16135787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16135787"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Monideepa Roy, Zhigang Li, David B Sacks "}, {"type": "b", "children": [{"type": "t", "text": "IQGAP1 binds ERK2 and modulates its activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M308405200"}], "href": "https://doi.org/10.1074/jbc.M308405200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14970219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14970219"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jian-Guo Ren, Zhigang Li, David B Sacks "}, {"type": "b", "children": [{"type": "t", "text": "IQGAP1 modulates activation of B-Raf."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0611308104"}], "href": "https://doi.org/10.1073/pnas.0611308104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17563371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17563371"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jennifer M Mataraza, Michael W Briggs, Zhigang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IQGAP1 promotes cell motility and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M304838200"}], "href": "https://doi.org/10.1074/jbc.M304838200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12900413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12900413"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mika Sakurai-Yageta, Chiara Recchi, Gaëlle Le Dez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200709076"}], "href": "https://doi.org/10.1083/jcb.200709076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18541705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18541705"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Minako Yamaoka-Tojo, Masuko Ushio-Fukai, Lula Hilenski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000136522.58649.60"}], "href": "https://doi.org/10.1161/01.RES.0000136522.58649.60"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15217908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15217908"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Satoshi Ikeda, Minako Yamaoka-Tojo, Lula Hilenski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.ATV.0000187472.55437.af"}], "href": "https://doi.org/10.1161/01.ATV.0000187472.55437.af"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16179592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16179592"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Dominique T Brandt, Sabrina Marion, Gareth Griffiths, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200612071"}], "href": "https://doi.org/10.1083/jcb.200612071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17620407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17620407"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mayuko Furuta, Ken-ich Kozaki, Shinji Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgp250"}], "href": "https://doi.org/10.1093/carcin/bgp250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19843643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19843643"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Valentina A Schmidt, Carmine S Chiariello, Encarnación Capilla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01090-07"}], "href": "https://doi.org/10.1128/MCB.01090-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18180285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18180285"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lorraine Jadeski, Jennifer M Mataraza, Ha-Won Jeong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M708466200"}], "href": "https://doi.org/10.1074/jbc.M708466200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17981797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17981797"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Scott C Mateer, Amanda E McDaniel, Valerie Nicolas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109535200"}], "href": "https://doi.org/10.1074/jbc.M109535200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11809768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11809768"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jun Noritake, Masaki Fukata, Kazumasa Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e03-08-0582"}], "href": "https://doi.org/10.1091/mbc.e03-08-0582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14699063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14699063"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Patricia Villacé, Rosa M Marión, Juan Ortín "}, {"type": "b", "children": [{"type": "t", "text": "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkh552"}], "href": "https://doi.org/10.1093/nar/gkh552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15121898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15121898"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sayeepriyadarshini Anakk, Manoj Bhosale, Valentina A Schmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bile acids activate YAP to promote liver carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2013.10.030"}], "href": "https://doi.org/10.1016/j.celrep.2013.10.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24268772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24268772"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Olivia Boyer, Geneviève Benoit, Olivier Gribouval, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in INF2 are a major cause of autosomal dominant focal segmental glomerulosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2010050518"}], "href": "https://doi.org/10.1681/ASN.2010050518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21258034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21258034"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Christophe Le Clainche, Dominik Schlaepfer, Aldo Ferrari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M607711200"}], "href": "https://doi.org/10.1074/jbc.M607711200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17085436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17085436"}]}]}]}
Synonyms	HUMORFA01, P195, SAR1
Proteins	IQGA1_HUMAN
NCBI Gene ID	8826
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IQGAP1 has 15,367 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 135 datasets.

Click the + buttons to view associations for IQGAP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IQGAP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by IQGAP1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IQGAP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IQGAP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IQGAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IQGAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IQGAP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IQGAP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IQGAP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IQGAP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IQGAP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IQGAP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IQGAP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IQGAP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IQGAP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IQGAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IQGAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing IQGAP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IQGAP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IQGAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IQGAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing IQGAP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing IQGAP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IQGAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IQGAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing IQGAP1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of IQGAP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IQGAP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IQGAP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IQGAP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IQGAP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with IQGAP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IQGAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IQGAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IQGAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IQGAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at IQGAP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IQGAP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of IQGAP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing IQGAP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of IQGAP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.