{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n IRAG2 (also known as lymphoid‐restricted membrane protein [LRMP] or Jaw1) is an endoplasmic reticulum–associated type II transmembrane protein that plays several interconnected roles in cell physiology. For example, in specialized sensory cells such as taste receptor cells, IRAG2 associates via its coiled‐coil domain with type III inositol 1,4,5‐triphosphate receptors to help mediate sweet, bitter, and umami taste transduction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In lymphoid tissues, IRAG2 is preferentially expressed in germinal center and related B cells, suggesting an important role in immune cell differentiation and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, genetic polymorphisms in the IRAG2 gene have been linked to autoimmune susceptibility—for instance in type 1 diabetes—as well as to altered growth properties in lung tumor cells, where allele‐specific variations may modulate clonogenic activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition to its role in signal transduction, IRAG2 contributes to the architectural organization of the endoplasmic reticulum and nuclear envelope by regulating its own oligomerization—a process critical for maintaining proper nuclear morphology and mechanotransduction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Finally, emerging evidence indicates that IRAG2 expression is also regulated by p53 in tuft cells, thereby influencing the intestinal type 2 immune response against parasitic infections."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these findings position IRAG2 as a multifunctional regulator linking intracellular Ca2+ signaling, immune modulation, and structural organization within cells.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yoichiro Shindo, Mi-Ryung Kim, Hirohito Miura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chem Senses (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/chemse/bjp097"}], "href": "https://doi.org/10.1093/chemse/bjp097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20071408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20071408"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S Tedoldi, J C Paterson, J Cordell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Jaw1/LRMP, a germinal centre-associated marker for the immunohistological study of B-cell lymphomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.2002"}], "href": "https://doi.org/10.1002/path.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16739114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16739114"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christina H Grimm, Ute C Rogner, Philip Avner "}, {"type": "b", "children": [{"type": "t", "text": "Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autoimmunity (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/0891693031000141068"}], "href": "https://doi.org/10.1080/0891693031000141068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14563018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14563018"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Federica Galbiati, Angela Pettinicchio, Tommaso A Dragani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2005.12.015"}], "href": "https://doi.org/10.1016/j.canlet.2005.12.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16458428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16458428"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Takuma Kozono, Hiroyuki Sato, Wataru Okumura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-80258-5"}], "href": "https://doi.org/10.1038/s41598-020-80258-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33436890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33436890"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chun-Yuan Chang, Jianming Wang, Yuhan Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressor p53 regulates intestinal type 2 immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-23587-x"}], "href": "https://doi.org/10.1038/s41467-021-23587-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34099671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34099671"}]}]}]}