{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent integrated analyses of competing endogenous RNA and co‐expression networks in osteoarthritic knee cartilage have identified ISM1‑AS1 as one of seven hub long non‑coding RNAs (lncRNAs) that may be central to osteoarthritis pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In this study, ISM1‑AS1, along with other key lncRNAs, was found to be differentially expressed when comparing osteoarthritic samples with normal cartilage. Enrichment analyses suggested that these lncRNAs are involved in the regulation of extracellular matrix organization and critical signaling pathways, including osteoclast differentiation, FoxO, and tumor necrosis factor (TNF) pathways, which are essential for maintaining chondrocyte homeostasis and could contribute to cartilage degradation in osteoarthritis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haitao Chen, Liaobin Chen "}, {"type": "b", "children": [{"type": "t", "text": "An integrated analysis of the competing endogenous RNA network and co-expression network revealed seven hub long non-coding RNAs in osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone Joint Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1302/2046-3758.93.BJR-2019-0140.R2"}], "href": "https://doi.org/10.1302/2046-3758.93.BJR-2019-0140.R2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32435461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32435461"}]}]}]}