{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study of low‐grade gliomas, ISX‑AS1 was identified as one of eight novel genomic instability‑associated long non‑coding RNAs (lncRNAs) derived from mutant profiles, alongside H19, FLG‑AS1, AC091932.1, AC064875.1, AL138767.3, AC010273.2, and AC131097.4."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Through comprehensive analyses that combined lncRNA expression profiles and somatic mutations, the investigators constructed a genomic instability‑associated lncRNA signature (GILncSig) to stratify patients into distinct risk groups based on prognostic outcomes. Notably, patients with a lower GILncSig score—a group exhibiting a higher rate of IDH1 mutations—demonstrated a better prognosis compared to those with higher scores. Although the study primarily formulated a prognostic tool, the inclusion of ISX‑AS1 in the signature highlights its potential role in mediating genomic instability and its possible value as a biomarker and therapeutic target in the management of low‑grade gliomas.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aierpati Maimaiti, Xixian Wang, Yinan Pei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and validation of a novel eight mutant-derived long non-coding RNAs signature as a prognostic biomarker for genome instability in low-grade glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203079"}], "href": "https://doi.org/10.18632/aging.203079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34081618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34081618"}]}]}]}