ITGAV Gene

HGNC Family	Integrins (ITG), CD molecules (CD)
Name	integrin, alpha V
Description	The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Integrin αV (ITGAV) is a versatile subunit that, by partnering with distinct β chains, forms heterodimers (such as αVβ3, αVβ1, αVβ6, and αVβ8) to regulate a wide spectrum of physiological and pathological processes. In the bone marrow microenvironment, ITGAV—commonly detected as CD51—is enriched on mesenchymal stromal cells that contribute to the hematopoietic stem cell niche, thereby supporting self‐renewal and stem cell maintenance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cancer, ITGAV‐containing integrins modulate cellular interactions with the extracellular matrix; for example, proteolytic processing by membrane‐type 1 matrix metalloproteinase (MT1‐MMP) regulates cell–ECM adhesion and migration, thereby promoting invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, ITGAV plays a central role in apoptotic cell clearance. Dendritic cells use ITGAV in the form of the αVβ3 vitronectin receptor to bind opsonized apoptotic cells, which not only enhances phagocytosis but also modulates subsequent immune responses"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "; similarly, MFG‐E8 bridges phosphatidylserine on target cells to ITGAV‐containing receptors, thereby mediating phagocytic removal of neuronal debris during neuroinflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n ITGAV is also pivotal in vascular biology. In endothelial cells, αVβ3 integrin participates in cross‐talk with vascular endothelial growth factor receptors to promote angiogenesis, a mechanism further modulated by extracellular lectins such as galectin‐3"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "and by mediating signaling that supports tumor cell survival and microvessel formation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "as well as receptor cross‐activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its roles in cell adhesion, ITGAV‐based receptors facilitate the activation of latent growth factors. Notably, the αVβ1 heterodimer directly binds the latency‐associated peptide of transforming growth factor–β1 (TGFβ1), thereby mediating its activation and contributing to the pathogenesis of tissue fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In the context of mesenchymal stem cell differentiation, signaling through the osteopontin–integrin αVβ1 axis influences the balance between osteogenesis and adipogenesis, with functional blockade skewing differentiation toward adipocyte formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, ITGAV adopts specialized roles in pathogen entry and immune modulation. Epithelial cells express ITGAV in association with β6 or β8, which serve as high‐affinity receptors for Epstein–Barr virus glycoprotein complexes, thereby triggering viral fusion and infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In autoimmune settings, osteopontin signaling via ITGAV‐containing receptors on T cells contributes to the promotion of proinflammatory cytokine production, thereby exacerbating disease processes such as experimental autoimmune encephalomyelitis and multiple sclerosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifaceted contributions of ITGAV in mediating cell adhesion, migration, immune regulation, angiogenesis, and tissue remodeling across diverse biological contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sandra Pinho, Julie Lacombe, Maher Hanoun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDGFRα and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20122252"}], "href": "https://doi.org/10.1084/jem.20122252"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23776077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23776077"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Motoharu Seiki "}, {"type": "b", "children": [{"type": "t", "text": "Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0304-3835(02)00699-7"}], "href": "https://doi.org/10.1016/s0304-3835(02"}, {"type": "t", "text": "00699-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12706853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12706853"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Erik H J Danen, Petra Sonneveld, Cord Brakebusch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200205014"}], "href": "https://doi.org/10.1083/jcb.200205014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12486108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12486108"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michael Fricker, Jonas J Neher, Jing-Wei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4837-11.2012"}], "href": "https://doi.org/10.1523/JNEUROSCI.4837-11.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22357850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22357850"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Anna I Markowska, Fu-Tong Liu, Noorjahan Panjwani "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20090121"}], "href": "https://doi.org/10.1084/jem.20090121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20713592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20713592"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Samuel C Mok, Tomas Bonome, Vinod Vathipadiekal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2009.10.018"}], "href": "https://doi.org/10.1016/j.ccr.2009.10.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19962670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19962670"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Payaningal R Somanath, Nikolay L Malinin, Tatiana V Byzova "}, {"type": "b", "children": [{"type": "t", "text": "Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Angiogenesis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10456-009-9141-9"}], "href": "https://doi.org/10.1007/s10456-009-9141-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19267251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19267251"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nilgun I Reed, Hyunil Jo, Chun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The αvβ1 integrin plays a critical in vivo role in tissue fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.aaa5094"}], "href": "https://doi.org/10.1126/scitranslmed.aaa5094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25995225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25995225"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Qing Chen, Peishun Shou, Liying Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.1567"}], "href": "https://doi.org/10.1002/stem.1567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24123709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24123709"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Liudmila S Chesnokova, Stephen L Nishimura, Lindsey M Hutt-Fletcher "}, {"type": "b", "children": [{"type": "t", "text": "Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0907508106"}], "href": "https://doi.org/10.1073/pnas.0907508106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19920174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19920174"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Gopal Murugaiyan, Akanksha Mittal, Howard L Weiner "}, {"type": "b", "children": [{"type": "t", "text": "Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.181.11.7480"}], "href": "https://doi.org/10.4049/jimmunol.181.11.7480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19017937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19017937"}]}]}]}
Synonyms	CD51, MSK8, VNRA, VTNR
Proteins	ITAV_HUMAN
NCBI Gene ID	3685
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ITGAV has 14,550 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 136 datasets.

Click the + buttons to view associations for ITGAV from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ITGAV Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ITGAV gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITGAV gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITGAV gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ITGAV gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ITGAV gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ITGAV gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITGAV gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving ITGAV protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ITGAV gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ITGAV gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ITGAV gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ITGAV gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ITGAV gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ITGAV gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with ITGAV gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ITGAV protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ITGAV gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ITGAV gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ITGAV gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ITGAV gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ITGAV protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ITGAV gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ITGAV protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ITGAV protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ITGAV protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ITGAV protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ITGAV protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ITGAV protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing ITGAV protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ITGAV gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ITGAV gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ITGAV gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ITGAV gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ITGAV protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ITGAV gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ITGAV gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ITGAV gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ITGAV gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ITGAV gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for ITGAV protein from the curated DrugBank Drug Targets dataset.