ITGB1BP1 Gene

Name	integrin beta 1 binding protein 1
Description	The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Integrin cytoplasmic domain‐associated protein‑1 (ICAP‑1), also known as ITGB1BP1, is a multifunctional adaptor that binds specifically to the NPXY motif in the cytoplasmic tail of β1 integrins through its phosphotyrosine‑binding domain, thereby antagonizing “inside–out” integrin activation and modulating cell adhesion dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In vascular cells, ICAP‑1 interacts with proteins such as KRIT1 to regulate integrin‐mediated signaling pathways that are critical for maintaining endothelial junction integrity and proper vascular morphogenesis, with perturbation of this pathway contributing to cerebral cavernous malformation pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, loss‐of‑function studies in osteoblasts have shown that absence of ITGB1BP1 enhances β1 integrin activation, resulting in increased cell adhesion and spreading but reduced proliferation and delayed bone mineralization, thereby affecting skeletal development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Complementarily, ICAP‑1 shuttles between the cytoplasm and nucleus, where it mediates downstream transcriptional events—such as activation of the c‑myc promoter—to couple integrin engagement with cell cycle progression and proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, by binding and translocating regulatory kinases like ROCK‑I to focal adhesion complexes, ITGB1BP1 further modulates actomyosin contractility and focal adhesion turnover, which in turn influences cell migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, the studies reviewed here demonstrate that ITGB1BP1 serves as a pivotal modulator of integrin‐dependent signaling, integrating extracellular matrix cues with intracellular responses that govern vascular stability, bone formation, and cell motility.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christina L Liquori, Michel J Berg, Adrian M Siegel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/380314"}], "href": "https://doi.org/10.1086/380314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14624391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14624391"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jon S Zawistowski, Ilya G Serebriiskii, Maximilian F Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/11.4.389"}], "href": "https://doi.org/10.1093/hmg/11.4.389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11854171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11854171"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "René Brütsch, Sven S Liebler, Joycelyn Wüstehube, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.110.217257"}], "href": "https://doi.org/10.1161/CIRCRESAHA.110.217257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20616313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20616313"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Daniel Bouvard, Attila Aszodi, Günter Kostka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective osteoblast function in ICAP-1-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.000877"}], "href": "https://doi.org/10.1242/dev.000877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17567669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17567669"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Henri-Noël Fournier, Sandra Dupé-Manet, Daniel Bouvard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e04-08-0744"}], "href": "https://doi.org/10.1091/mbc.e04-08-0744"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15703214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15703214"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Peter J M Stroeken, Belén Alvarez, Jacco Van Rheenen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.20699"}], "href": "https://doi.org/10.1002/jcp.20699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16741948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16741948"}]}]}]}
Synonyms	ICAP-1B, ICAP-1ALPHA, ICAP1, ICAP-1A, ICAP1A, ICAP1B
Proteins	ITBP1_HUMAN
NCBI Gene ID	9270
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ITGB1BP1 has 7,749 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for ITGB1BP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ITGB1BP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITGB1BP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITGB1BP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ITGB1BP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ITGB1BP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ITGB1BP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITGB1BP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ITGB1BP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ITGB1BP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ITGB1BP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ITGB1BP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ITGB1BP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ITGB1BP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ITGB1BP1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ITGB1BP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ITGB1BP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ITGB1BP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ITGB1BP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ITGB1BP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ITGB1BP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ITGB1BP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ITGB1BP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ITGB1BP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ITGB1BP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ITGB1BP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ITGB1BP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ITGB1BP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ITGB1BP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ITGB1BP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ITGB1BP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ITGB1BP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ITGB1BP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ITGB1BP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ITGB1BP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ITGB1BP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ITGB1BP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ITGB1BP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ITGB1BP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ITGB1BP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ITGB1BP1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of ITGB1BP1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.