{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have underscored the importance of long non‐coding RNAs (lncRNAs) in diverse human diseases ranging from metabolic dysregulation to cancer. Genome‐wide association analyses have identified genetic variants that influence adipose tissue distribution and metabolic traits"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", while separate investigations into cholangiocarcinoma have revealed that altered lncRNA expression may impact pathways related to cholesterol homeostasis and lipid binding."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In this context, a novel lncRNA, ITIH4‐AS1, has emerged as a critical pro‐tumorigenic factor in colorectal cancer. Although ITIH4‐AS1 is barely detectable in most normal tissues including the colon, its expression is markedly upregulated in colorectal cancer cells. This aberrant expression is attributed to the downregulation of the transcriptional repressor REST, which normally keeps ITIH4‐AS1 levels low. Functionally, elevated ITIH4‐AS1 facilitates colorectal cancer cell growth and metastasis through activation of the JAK/STAT3 pathway. Mechanistic studies revealed that ITIH4‐AS1 recruits the RNA‐binding protein FUS, which in turn mediates the nuclear translocation of phosphorylated STAT3, thereby promoting downstream oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Wang, Xiaojing Ma, Danfeng Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep20691"}], "href": "https://doi.org/10.1038/srep20691"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26848030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26848030"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenhui Yang, Yuan Li, Xia Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analysis of long noncoding RNA and mRNA co-expression profile in intrahepatic cholangiocarcinoma tissue by RNA sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15721"}], "href": "https://doi.org/10.18632/oncotarget.15721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28427159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28427159"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chaojie Liang, Tuanjie Zhao, Haijun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA ITIH4-AS1 Accelerates the Proliferation and Metastasis of Colorectal Cancer by Activating JAK/STAT3 Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2019.08.009"}], "href": "https://doi.org/10.1016/j.omtn.2019.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31557619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31557619"}]}]}]}