ITPA Gene

Name	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Description	This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The inosine triphosphate pyrophosphatase (ITPase) enzyme, which is encoded by the ITPA gene, plays a central role in “sanitizing” the intracellular nucleotide pool by hydrolyzing noncanonical purine nucleotides—most notably inosine triphosphate (ITP)—to their corresponding monophosphate (IMP). In doing so, ITPase helps to prevent the aberrant incorporation of deaminated nucleotides into nucleic acids, thereby maintaining genomic and transcript integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Common ITPA polymorphisms—most notably the 94C>A variant that results in a proline‐to‐threonine substitution (P32T) and certain splicing alterations—impair ITPase activity and lead to the accumulation of nonhydrolyzed inosine nucleotides. Although ITPase deficiency is generally well tolerated under basal conditions, these genetic variants have profound pharmacogenetic implications. For example, in hepatitis C treatment regimens that include ribavirin, patients harboring ITPA deficiency variants are protected from drug‐induced hemolytic anemia, thereby aiding in treatment adherence."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, during thiopurine therapy for conditions such as inflammatory bowel disease or acute lymphoblastic leukemia, deficient ITPase activity is associated with higher risks of adverse drug reactions—including flu‐like symptoms, rash, pancreatitis, and leukopenia—presumably due to the buildup of toxic thiopurine metabolites."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, the ITPA polymorphic status has been incorporated into pharmacogenetic models aimed at predicting therapeutic responses to drugs such as methotrexate in rheumatoid arthritis, highlighting its emerging relevance in personalized medicine."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, studies in murine models indicate that complete ITPA deficiency can adversely affect cellular functions—such as the proper organization of cardiac sarcomeres—further underscoring the enzyme’s importance in nucleotide quality control and overall cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings demonstrate that ITPase not only safeguards the fidelity of nucleic acid synthesis but also significantly modulates drug efficacy and toxicity profiles, making ITPA an important target for pharmacogenetic screening and individualized treatment strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Henian Cao, Robert A Hegele "}, {"type": "b", "children": [{"type": "t", "text": "DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s100380200095"}], "href": "https://doi.org/10.1007/s100380200095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12436200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12436200"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Elena I Stepchenkova, Elena R Tarakhovskaya, Kathryn Spitler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional study of the P32T ITPA variant associated with drug sensitivity in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2009.07.051"}], "href": "https://doi.org/10.1016/j.jmb.2009.07.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19631656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19631656"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Monica Arenas, John Duley, Satoshi Sumi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2006.10.006"}], "href": "https://doi.org/10.1016/j.bbadis.2006.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17113761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17113761"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tohru Maeda, Satoshi Sumi, Akihito Ueta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2005.03.011"}], "href": "https://doi.org/10.1016/j.ymgme.2005.03.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15946879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15946879"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jacques Fellay, Alexander J Thompson, Dongliang Ge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08825"}], "href": "https://doi.org/10.1038/nature08825"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20173735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20173735"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Alexander J Thompson, Jacques Fellay, Keyur Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2010.06.016"}], "href": "https://doi.org/10.1053/j.gastro.2010.06.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20547162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20547162"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fumitaka Suzuki, Yoshiyuki Suzuki, Norio Akuta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.24058"}], "href": "https://doi.org/10.1002/hep.24058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21246582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21246582"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Naoya Sakamoto, Yasuhito Tanaka, Mina Nakagawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ITPA gene variant protects against anemia induced by pegylated interferon-α and ribavirin therapy for Japanese patients with chronic hepatitis C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatol Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1872-034X.2010.00741.x"}], "href": "https://doi.org/10.1111/j.1872-034X.2010.00741.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20977565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20977565"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Anthony M Marinaki, Azhar Ansari, John A Duley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenetics (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00008571-200403000-00006"}], "href": "https://doi.org/10.1097/00008571-200403000-00006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15167706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15167706"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "A Ansari, M Arenas, S M Greenfield, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aliment Pharmacol Ther (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2036.2008.03788.x"}], "href": "https://doi.org/10.1111/j.1365-2036.2008.03788.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18616518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18616518"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zuzana Zelinkova, Luc J J Derijks, Pieter C F Stokkers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Gastroenterol Hepatol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cgh.2005.10.019"}], "href": "https://doi.org/10.1016/j.cgh.2005.10.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16431304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16431304"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kan Uchiyama, Makoto Nakamura, Takahiro Kubota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00535-008-2307-1"}], "href": "https://doi.org/10.1007/s00535-008-2307-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19214663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19214663"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "A M Marinaki, J A Duley, M Arenas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation in the ITPA gene predicts intolerance to azathioprine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleosides Nucleotides Nucleic Acids (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1081/NCN-200027639"}], "href": "https://doi.org/10.1081/NCN-200027639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15571265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15571265"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Judith A M Wessels, Sjoerd M van der Kooij, Saskia le Cessie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.22640"}], "href": "https://doi.org/10.1002/art.22640"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17530705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17530705"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Judith A M Wessels, Wouter M Kooloos, Robert De Jonge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.22032"}], "href": "https://doi.org/10.1002/art.22032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16947783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16947783"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Thierry Dervieux, Judith A M Wessels, Tahar van der Straaten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0b013e32833315d1"}], "href": "https://doi.org/10.1097/FPC.0b013e32833315d1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19858780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19858780"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "M Behmanesh, K Sakumi, N Abolhassani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ITPase-deficient mice show growth retardation and die before weaning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2009.53"}], "href": "https://doi.org/10.1038/cdd.2009.53"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19498443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19498443"}]}]}]}
Synonyms	NTPase, DJ794I6.3, ITPase, C20ORF37, HLC14-06-P, MY049
Proteins	ITPA_HUMAN
NCBI Gene ID	3704
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ITPA has 6,435 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 135 datasets.

Click the + buttons to view associations for ITPA from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ITPA Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITPA gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITPA gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ITPA gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ITPA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ITPA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITPA gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ITPA gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ITPA gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ITPA gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ITPA gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ITPA gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ITPA gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ITPA protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ITPA gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ITPA gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ITPA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ITPA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with ITPA gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ITPA gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ITPA protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ITPA gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ITPA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ITPA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ITPA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ITPA gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ITPA gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ITPA gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ITPA gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ITPA gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ITPA protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ITPA gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ITPA gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ITPA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ITPA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ITPA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ITPA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ITPA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ITPA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for ITPA protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ITPA gene from the ENCODE Histone Modification Site Profiles dataset.