{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe long non-coding RNA ITPR1-AS1 is notably upregulated in small cell lung cancer (SCLC) tissues, particularly in those with lymph node metastasis, and its increased expression correlates with enhanced malignant characteristics and reduced overall survival in patients. This finding designates ITPR1-AS1 as an independent prognostic factor in SCLC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn mechanistic terms, ITPR1-AS1 functions as a molecular scaffold by facilitating the interaction between SRC-associated in mitosis 68 kDa and heterogeneous nuclear ribonucleoprotein A1. This complex promotes the alternative splicing of the HRAS pre-mRNA, leading to the generation of an oncogenic splice variant known as P21HRAS, which plays a pivotal role in initiating metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nFurthermore, ITPR1-AS1 is involved in regulating protein stability by associating with the DEAD-box polypeptide 3 (DDX3X). Through this interaction, ITPR1-AS1 prevents DDX3X from ubiquitination and subsequent degradation, thereby sustaining DDX3X levels and contributing to the activation of the cRaf-MEK-ERK cascade—a signaling pathway that further drives the metastatic progression of SCLC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Quanli Zhang, Limin Zheng, Yongkang Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ITPR1-AS1 promotes small cell lung cancer metastasis by facilitating P21"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "HRAS"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " splicing and stabilizing DDX3X to activate the cRaf-MEK-ERK cascade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2023.216426"}], "href": "https://doi.org/10.1016/j.canlet.2023.216426"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37820992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37820992"}]}]}]}