{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA JADE (lncRNA‐JADE) is emerging as a critical regulator that bridges the DNA damage response (DDR) with chromatin remodeling. In response to DNA damage, lncRNA‐JADE is induced in an ATM‐dependent manner and, in turn, transcriptionally activates the expression of Jade1—a key component of the HBO1 histone acetylation complex. The upregulation of Jade1 promotes histone H4 acetylation, a modification that likely facilitates chromatin opening and the efficient execution of DNA repair mechanisms. This signaling axis is particularly important in the context of tumor biology, as elevated levels of lncRNA‐JADE have been observed in human breast tumors, and its knockdown has been shown to significantly inhibit tumor growth. In parallel, studies of the JADE protein family (which includes JADE1, JADE2, and JADE3) reveal that these proteins, through their conserved PHD zinc‐finger domains, not only contribute to the acetylation machinery but also play roles in epithelial cell cycle regulation and the maintenance of genomic stability. Together, the lncRNA‐JADE/Jade1 pathway provides a molecular link between DNA damage signaling and epigenetic regulation, underscoring its potential importance in both normal cellular homeostasis and oncogenic transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guohui Wan, Xiaoxiao Hu, Yunhua Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2013.221"}], "href": "https://doi.org/10.1038/emboj.2013.221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24097061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24097061"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maria V Panchenko "}, {"type": "b", "children": [{"type": "t", "text": "Structure, function and regulation of jade family PHD finger 1 (JADE1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2016.05.002"}], "href": "https://doi.org/10.1016/j.gene.2016.05.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27155521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27155521"}]}]}]}