{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent transcriptomic studies have begun to unveil potential roles for the long noncoding RNA JAKMIP2‐AS1 in diverse biological contexts. Although an extensive analysis of human pluripotent stem cell–derived hepatocytes revealed many candidate regulatory targets for improving hepatocyte functionality (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", subsequent investigations have specifically implicated JAKMIP2‐AS1 in disease‐related processes. In ovarian endometriosis, network‐based analyses identified JAKMIP2‐AS1 as one of the top hub long noncoding RNAs within a competing endogenous RNA framework; here, it is proposed to participate in the regulation of immune cell activation, phagocytosis, and tissue remodeling events that may drive the pathogenesis of the disorder."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In a separate context, studies in colorectal cancer demonstrated that JAKMIP2‐AS1 is significantly upregulated in tumor tissues and cell lines. Its overexpression is associated with enhanced cell proliferation, increased tumor growth in vivo, and ultimately, a poorer prognosis for patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these findings suggest that JAKMIP2‐AS1 may function as a critical regulatory node in both modulating inflammatory/tissue remodeling responses and promoting malignant cell proliferation, highlighting its potential as a molecular marker and therapeutic target in these conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nidal Ghosheh, Barbara Küppers-Munther, Annika Asplund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Pluripotent Stem Cell-Derived Hepatocytes Show Higher Transcriptional Correlation with Adult Liver Tissue than with Fetal Liver Tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "ACS Omega (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acsomega.9b03514"}], "href": "https://doi.org/10.1021/acsomega.9b03514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32201767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32201767"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chenglei Gu, Yuanguang Meng, Qingqing Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exploring the Potential Key IncRNAs with Endometriosis by Construction of a ceRNA Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gen Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/IJGM.S321648"}], "href": "https://doi.org/10.2147/IJGM.S321648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34385836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34385836"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tianyi Ma, Tianyu Qiao, Ziming Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA JAKMIP2-AS1 Promotes the Growth of Colorectal Cancer and Indicates Poor Prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S289617"}], "href": "https://doi.org/10.2147/OTT.S289617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33568916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33568916"}]}]}]}