{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n JHDM1D‐AS1, a long non‐coding RNA, has emerged as a versatile regulator whose function is highly context dependent. In cancer settings, elevated JHDM1D‐AS1 expression contributes to tumor progression. In gastric cancer, for instance, it acts as a competing endogenous RNA by sponging miR‑450a‑2‑3p to upregulate PRAF2, thereby promoting cell proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, in pancreatic cancer under nutrient starvation and in non–small‐cell lung cancer, JHDM1D‐AS1 is overexpressed where it not only induces angiogenesis but also drives metastasis by stabilizing the oncogenic protein DHX15, correlating with advanced disease stage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Conversely, in non–cancer contexts JHDM1D‐AS1 exhibits protective roles. In periodontal ligament stem cells exposed to oxidative stress, a rapid downregulation of JHDM1D‐AS1 is linked with enhanced apoptosis; under normal conditions, JHDM1D‐AS1 suppresses apoptosis via inhibition of DNAJC10 and modulation of downstream anti‐apoptotic factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In models of Parkinson’s disease, reduced levels of JHDM1D‐AS1 are associated with increased neuronal apoptosis, inflammation, and oxidative stress, while its overexpression attenuates MPP⁺‑induced injury by sponging miR‑134‑5p to upregulate PIK3R3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in a rat model of traumatic brachial plexus injury, JHDM1D‐AS1 confers neuroprotection by acting as a competitive endogenous RNA for miR‑101‑3p, thereby restoring DUSP1 expression to suppress neuroinflammation and neuronal apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the dual role of JHDM1D‐AS1 in regulating angiogenesis, cell survival, and inflammation across diverse cellular environments, highlighting its potential as a therapeutic target in both oncologic and neurodegenerative disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Min Wu, Yi Liu, Yan-Song Pu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JHDM1D-AS1 aggravates the development of gastric cancer through miR-450a-2-3p-PRAF2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.118805"}], "href": "https://doi.org/10.1016/j.lfs.2020.118805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33245963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33245963"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ayano Kondo, Aya Nonaka, Teppei Shimamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00125-17"}], "href": "https://doi.org/10.1128/MCB.00125-17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28652266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28652266"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guodong Yao, Kexin Chen, Yu Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA JHDM1D-AS1 Interacts with DHX15 Protein to Enhance Non-Small-Cell Lung Cancer Growth and Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2019.09.028"}], "href": "https://doi.org/10.1016/j.omtn.2019.09.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31739208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31739208"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bai Shi, Bingyi Shao, Chonshi Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of JHDM1D-AS1 protects PDLSCs from H"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "O"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "-induced apoptosis by decreasing DNAJC10 via phosphorylation of eIF2α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2019.06.018"}], "href": "https://doi.org/10.1016/j.biochi.2019.06.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31276733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31276733"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Cuihui Wang, Hongying Zhang, Ji Li "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA JHDM1D-AS1 Suppresses MPP + -Induced Neuronal Injury in Parkinson's Disease via miR-134-5p/PIK3R3 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurotox Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12640-021-00437-8"}], "href": "https://doi.org/10.1007/s12640-021-00437-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34773593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34773593"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lu-Ping Liu, Jie Zhang, Bo Pu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of JHDM1D-AS1 alleviates neuroinflammation and neuronal injury via targeting miR-101-3p-DUSP1 in spinal cord after brachial plexus injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2020.106962"}], "href": "https://doi.org/10.1016/j.intimp.2020.106962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33039970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33039970"}]}]}]}