{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Jupiter microtubule‐associated homolog 1 (JPT1) has emerged as a multifunctional protein with potential clinical utility in cancer. In endometrioid endometrial cancer, proteomic profiling revealed that patients who respond to metformin treatment exhibit significantly elevated JPT1 levels prior to therapy, with a marked decrease in its abundance following treatment. This observation supports the role of JPT1 as both a predictive and pharmacodynamic biomarker for metformin response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In prostate cancer, JPT1 is regulated by a competing endogenous RNA mechanism in which the long noncoding RNA HOXA11‐AS sequesters microRNA‐24–3p, thereby elevating JPT1 expression. Enhanced JPT1 levels in this context correlate with increased cell proliferation, colony formation, invasion, and ultimately contribute to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, studies in gastric cancer have identified a circular RNA form derived from the JPT1 transcript (circ_HN1) that is overexpressed in tumors; depletion of circ_HN1 disrupts malignant behaviors such as proliferation, spheroid formation, invasion, and migration while inducing apoptosis, further underscoring the oncogenic potential of JPT1‐related transcripts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that JPT1 not only serves as a valuable biomarker for monitoring therapeutic response but also functions in oncogenic signaling pathways that drive tumor aggressiveness across multiple cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nicholas W Bateman, Pang-Ning Teng, Erica Hope, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Jupiter microtubule-associated homolog 1 (JPT1): A predictive and pharmacodynamic biomarker of metformin response in endometrial cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2729"}], "href": "https://doi.org/10.1002/cam4.2729"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31808620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31808620"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Y Cheng, H-Y Xiong, Y-M Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA HOXA11-AS promotes cell growth by sponging miR-24-3p to regulate JPT1 in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202107_26377"}], "href": "https://doi.org/10.26355/eurrev_202107_26377"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34337714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34337714"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianmin Zhang, Fang Wang, Haihui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel circular RNA circ_HN1/miR-628-5p/Ecto-5'-nucleotidase competing endogenous RNA network regulates gastric cancer development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1989259"}], "href": "https://doi.org/10.1080/21655979.2021.1989259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34637682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34637682"}]}]}]}