{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KANTR is a long intergenic non‐coding RNA (lincRNA) that appears to play an essential role in mammalian development and tissue homeostasis. In a knockout study of various lincRNAs, disruption of genes such as KANTR led to a spectrum of phenotypes—including perinatal lethality and defects affecting the lungs, skeleton, and muscle—highlighting its importance during embryogenesis and later physiological function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " The detailed spatial and temporal expression patterns revealed by a lacZ reporter further suggest that KANTR is dynamically regulated across multiple tissues, underscoring its potential for fine-tuning developmental pathways. In addition, analyses of allele-specific transcription and chromatin structure in studies of X chromosome inactivation have provided insights into the regulatory environments where escape from silencing occurs; although this work does not directly target KANTR, it supports the concept that lincRNAs like KANTR may contribute to the maintenance of open chromatin states and proper gene dosage in a tissue-specific manner."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " While clinical investigations—such as trials assessing the prophylactic use of verapamil in transradial procedures—focus on unrelated therapeutic interventions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", progress in transcriptome annotation driven by long-read sequencing is expected to refine our understanding of poorly characterized lincRNAs, including KANTR, across the human lifespan."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ka-Man Venus Lai, Guochun Gong, Amanda Atanasio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0125522"}], "href": "https://doi.org/10.1371/journal.pone.0125522"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25909911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25909911"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Joel B Berletch, Wenxiu Ma, Fan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Escape from X inactivation varies in mouse tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1005079"}], "href": "https://doi.org/10.1371/journal.pgen.1005079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25785854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25785854"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Istvan Hizoh, Zsuzsanna Majoros, Laszlo Major, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Need for prophylactic application of verapamil in transradial coronary procedures: a randomized trial. The VITRIOL (is Verapamil In TransRadial Interventions OmittabLe?) trial."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.113.000588"}], "href": "https://doi.org/10.1161/JAHA.113.000588"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24732918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24732918"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Barbara Uszczynska-Ratajczak, Julien Lagarde, Adam Frankish, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Towards a complete map of the human long non-coding RNA transcriptome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41576-018-0017-y"}], "href": "https://doi.org/10.1038/s41576-018-0017-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29795125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29795125"}]}]}]}