{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KBTBD11‐OT1 is a long non‐coding RNA (lncRNA) that appears to be involved in the regulation of gene expression in both physiological and pathophysiological contexts. In studies of the human heart, a broad survey of structural genomic variants demonstrated that variants can affect transcripts from all classes—including lncRNAs such as KBTBD11‐OT1—suggesting that modulation of its expression may contribute to the fine‐tuning of the cardiac transcriptome and ultimately to phenotypic variability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Similarly, in colorectal cancer, integrative analyses revealed that copy number variations (CNVs) are associated with aberrant expression of lncRNAs, which play key roles in tumorigenesis and patient prognosis. Although KBTBD11‐OT1 was not singled out in the final CNV signature, its classification as a lncRNA implies that it may be part of the broader regulatory network impacted by genomic and epigenomic aberrations, thereby contributing to cancer development and serving as a potential biomarker for prognostic management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings underscore the significance of lncRNAs like KBTBD11‐OT1 in mediating gene regulatory networks that are affected by structural variations and copy number changes, highlighting their emerging roles in both cardiac biology and oncogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jan Haas, Stefan Mester, Alan Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic structural variations lead to dysregulation of important coding and non-coding RNA species in dilated cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201707838"}], "href": "https://doi.org/10.15252/emmm.201707838"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29138229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29138229"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huimin Liu, Xiaoyu Gu, Guihua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Copy number variations primed lncRNAs deregulation contribute to poor prognosis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102168"}], "href": "https://doi.org/10.18632/aging.102168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31442207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31442207"}]}]}]}