KCNJ12 Gene

HGNC Family	Ion channels
Name	potassium channel, inwardly rectifying subfamily J, member 12
Description	This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Kir2.2 channels, encoded by the KCNJ12 gene, are critical determinants of the inwardly rectifying K⁺ current that helps stabilize resting membrane potential and set cellular excitability in many tissues. In cardiac myocytes, Kir2.2 contributes to the classical IK₁ current—often coassembling with Kir2.1 and Kir2.3 subunits—to shape action potential duration and influence arrhythmia susceptibility; indeed, reduced expression of Kir2.2 (along with Kir2.1) is linked to long QT syndromes and other arrhythmogenic conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In neurons and astrocytes, Kir2.2 helps set the membrane potential and regulate signal integration, with studies showing that neuronal inward rectifier currents attributable to Kir2.2 (often together with Kir2.3) influence dendritic processing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Endothelial cells also rely on Kir2.2 for maintaining their resting membrane potential, as evidenced by predominant Kir2.2 protein expression and functional studies in human aortic endothelial cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Biophysical analyses using concatenated channel approaches have demonstrated that heteromeric channels containing Kir2.2 contribute distinctively to single‐channel conductance and gating kinetics, with Kir2.2 subunits exhibiting characteristic sensitivities to intracellular polyamines and PIP₂ levels. Direct activation of Kir2.2 by PIP₂ and its modulation by intracellular factors such as phosphorylation via protein kinase C (PKC) underlie its dynamic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In mesenchymal stem cells, Kir2.2 expression is associated with enhanced proliferative capacity, and its trafficking (often influenced by coassembly with other Kir2 subunits) impacts overall channel surface expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In immune cells, stimulation through Toll-like receptor 4 drives the PKC-dependent translocation of Kir2.2 to the plasma membrane; such regulation is important for modulating Ca²⁺ signaling and cytokine release."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, pharmacological studies reveal that drugs may affect inward rectifier channels in an isoform-specific manner, with some agents failing to modulate Kir2.2–containing channels, emphasizing the necessity to consider channel subunit composition when developing therapeutic interventions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, recent cancer studies have unveiled novel roles for Kir2.2 beyond maintaining membrane potential. In cancer cells, knockdown of Kir2.2 induces senescence through reactive oxygen species generation and cell cycle arrest"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", while in bladder cancer a regulatory axis involving a circular RNA and miR‑132‑3p modulates KCNJ12 expression to promote oncogenesis, epithelial–mesenchymal transition, and activate GSK3β/AKT signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, the KCNJ12-encoded Kir2.2 channels play multifaceted roles in controlling cellular excitability, signal integration, and even cell proliferation and differentiation. These properties make them attractive targets for therapeutic interventions in cardiovascular, neurological, immunological, and oncological disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_fs", "start_ref": "5", "end_ref": "9"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Regina Preisig-Müller, Günter Schlichthörl, Tobias Goerge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.102609499"}], "href": "https://doi.org/10.1073/pnas.102609499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12032359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12032359"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andrea A Domenighetti, Christophe Boixel, Daniel Cefai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic angiotensin II stimulation in the heart produces an acquired long QT syndrome associated with IK1 potassium current downregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2006.09.019"}], "href": "https://doi.org/10.1016/j.yjmcc.2006.09.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17070838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17070838"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marcos Matamoros, Marta Pérez-Hernández, Guadalupe Guerrero-Serna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvw009"}], "href": "https://doi.org/10.1093/cvr/cvw009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26786162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26786162"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michelle Day, David B Carr, Sasha Ulrich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2650-05.2005"}], "href": "https://doi.org/10.1523/JNEUROSCI.2650-05.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16177047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16177047"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yun Fang, Gernot Schram, Victor G Romanenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00077.2005"}], "href": "https://doi.org/10.1152/ajpcell.00077.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15958527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15958527"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Brian K Panama, Meredith McLerie, Anatoli N Lopatin "}, {"type": "b", "children": [{"type": "t", "text": "Functional consequences of Kir2.1/Kir2.2 subunit heteromerization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-010-0864-7"}], "href": "https://doi.org/10.1007/s00424-010-0864-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20676672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20676672"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nazzareno D'Avanzo, Wayland W L Cheng, Declan A Doyle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C110.186692"}], "href": "https://doi.org/10.1074/jbc.C110.186692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20921230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20921230"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jiao Zhang, Yau-Chi Chan, Jenny Chung-Yee Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00326.2011"}], "href": "https://doi.org/10.1152/ajpcell.00326.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22357737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22357737"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lior Dassau, Lisa R Conti, Carolyn M Radeke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kir2.6 regulates the surface expression of Kir2.x inward rectifier potassium channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.170597"}], "href": "https://doi.org/10.1074/jbc.M110.170597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21209095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21209095"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kyung Soo Kim, Ji Hyun Jang, Haiyue Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rise and Fall of Kir2.2 Current by TLR4 Signaling in Human Monocytes: PKC-Dependent Trafficking and PI3K-Mediated PIP2 Decrease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1500056"}], "href": "https://doi.org/10.4049/jimmunol.1500056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26324774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26324774"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ricardo Gómez, Ricardo Caballero, Adriana Barana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvu203"}], "href": "https://doi.org/10.1093/cvr/cvu203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25205296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25205296"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Inkyoung Lee, Chaehwa Park, Won Ki Kang "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of inwardly rectifying potassium channel Kir2.2 suppresses tumorigenesis by inducing reactive oxygen species-mediated cellular senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-10-0511"}], "href": "https://doi.org/10.1158/1535-7163.MCT-10-0511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20841375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20841375"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Gang Li, Bao-Yin Guo, Hua-Dong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA hsa_circ_0014130 function as a miR-132-3p sponge for playing oncogenic roles in bladder cancer via upregulating KCNJ12 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10565-021-09668-z"}], "href": "https://doi.org/10.1007/s10565-021-09668-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34755307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34755307"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Brian K Panama, Anatoli N Lopatin "}, {"type": "b", "children": [{"type": "t", "text": "Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2005.097741"}], "href": "https://doi.org/10.1113/jphysiol.2005.097741"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16373386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16373386"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Claudia Kiesecker, Edgar Zitron, Daniel Scherer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-005-0707-8"}], "href": "https://doi.org/10.1007/s00109-005-0707-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16258766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16258766"}]}]}]}
Synonyms	KIR2.2V, HIRK1, KCNJN1, HKIR2.2X, KIR2.2, KCNJ12X, IRK2, IRK-2, HIRK
Proteins	KCJ12_HUMAN
NCBI Gene ID	3768
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KCNJ12 has 4,833 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.

Click the + buttons to view associations for KCNJ12 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KCNJ12 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNJ12 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNJ12 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KCNJ12 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KCNJ12 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KCNJ12 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNJ12 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNJ12 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCNJ12 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCNJ12 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of KCNJ12 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCNJ12 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNJ12 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNJ12 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KCNJ12 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KCNJ12 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KCNJ12 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KCNJ12 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KCNJ12 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KCNJ12 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KCNJ12 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCNJ12 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KCNJ12 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KCNJ12 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KCNJ12 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KCNJ12 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KCNJ12 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KCNJ12 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KCNJ12 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for KCNJ12 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KCNJ12 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNJ12 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KCNJ12 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KCNJ12 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with KCNJ12 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with KCNJ12 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNJ12 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with KCNJ12 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing KCNJ12 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of KCNJ12 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of KCNJ12 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.