{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KCNJ2‐AS1 is a long noncoding (antisense) RNA transcript that appears to have multifaceted functions in human disease. On one hand, genetic studies have linked variants in a lincRNA at the 17q24.3 locus—likely corresponding to KCNJ2‐AS1—to thyrotoxic periodic paralysis, a condition characterized by severe muscle weakness and hypokalemia. This association suggests that KCNJ2‐AS1 may play a role in modulating the expression or function of the nearby KCNJ2 gene, which encodes an inwardly rectifying potassium channel crucial for maintaining muscle excitability and ion balance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n On the other hand, KCNJ2‐AS1 has also been identified as one of several long noncoding RNA biomarkers that collectively predict disease‐free survival in gastric cancer patients. Its inclusion in a prognostic signature indicates that altered expression of KCNJ2‐AS1 may be linked to tumor progression or the overall malignant phenotype, thereby serving as a potential noninvasive biomarker to guide preoperative risk stratification and treatment decisions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, although the precise molecular mechanisms remain to be fully elucidated, current evidence indicates that KCNJ2‐AS1 can influence critical cellular pathways—ranging from ion channel regulation in neuromuscular disorders to factors impacting tumor behavior in cancer. These dual roles underscore its importance both as a mediator of disease pathogenesis and as a promising prognostic indicator.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maria Clara C Melo, Janaína S de Souza, Marina M L Kizys, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel lincRNA Susceptibility Gene and Its Role in Etiopathogenesis of Thyrotoxic Periodic Paralysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocr Soc (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/js.2017-00015"}], "href": "https://doi.org/10.1210/js.2017-00015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29264532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29264532"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Canchang Cheng, Qicai Wang, Minggu Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis reveals potential long non-coding RNA biomarkers and their potential biological functions for disease free survival in gastric cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-019-0846-6"}], "href": "https://doi.org/10.1186/s12935-019-0846-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31080364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31080364"}]}]}]}