{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA KCNK15‐AS1 has emerged as an important regulator in cancer, albeit with context‐dependent functions. In pancreatic and gastric cancer, KCNK15‐AS1 is reported to be downregulated, and its expression inversely correlates with tumor aggressiveness. In pancreatic cancer, reduced levels of KCNK15‐AS1 are associated with enhanced migration, invasion, and epithelial–mesenchymal transition, while its enforced expression suppresses these malignant phenotypes. Notably, its activity is modulated by N6‐methyladenosine (m6A) modification; the m6A “eraser” ALKBH5 directly demethylates KCNK15‐AS1, thereby regulating pancreatic cancer cell motility"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In gastric cancer, epigenetic silencing through promoter methylation contributes to its low expression. Mechanistic studies have demonstrated that KCNK15‐AS1 can interact with epigenetic modifiers such as DNMT1 and HDAC1 to influence downstream signaling cascades—including MAPK, AKT, and STAT5 pathways—resulting in suppressed cell proliferation and enhanced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In contrast, studies in lung adenocarcinoma reveal that KCNK15‐AS1 is overexpressed, where its high levels are correlated with poor prognosis. Silencing of KCNK15‐AS1 in lung cancer cells leads to reduced proliferation by affecting the miR‐202/miR‐370/EGFR signaling axis, indicating an oncogenic role in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuan He, Hao Hu, Yandong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000491915"}], "href": "https://doi.org/10.1159/000491915"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30032148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30032148"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuan He, HongQin Yue, Ying Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ALKBH5-mediated m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04401-4"}], "href": "https://doi.org/10.1038/s41419-021-04401-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34853296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34853296"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Haiyan Zhang, Zhuo Zhang, Dayu Wang "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of IncRNA KCNKI5-ASI in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S186002"}], "href": "https://doi.org/10.2147/CMAR.S186002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31572012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31572012"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jun Peng, Xin-Long Chen, Hong-Zhong Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of KCNK15-AS1 inhibits lung cancer cell proliferation via upregulation of miR-202 and miR-370."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2019.10944"}], "href": "https://doi.org/10.3892/ol.2019.10944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31788071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31788071"}]}]}]}