KCNK5 Gene

HGNC Family	Ion channels
Name	potassium channel, two pore domain subfamily K, member 5
Description	This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KCNK5, which encodes the acid‐sensitive two‐pore domain potassium channel known as TASK‐2, plays a pivotal role in regulating ion homeostasis by mediating leak K⁺ currents that are exquisitely sensitive to both extracellular and intracellular pH changes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In renal epithelial cells TASK‐2 is critically involved in bicarbonate reabsorption and the apoptotic volume decrease necessary for cell survival, thereby contributing to the maintenance of acid–base balance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " TASK‐2 also participates in central respiratory chemoreception; its activity in brainstem chemosensitive regions modulates the ventilatory response to changes in CO₂/H⁺ levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In the immune system, TASK‐2 is upregulated upon lymphocyte activation, where it helps maintain a hyperpolarized membrane potential that facilitates Ca²⁺ influx and proper volume regulation during T‐ and B‐cell responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, genetic and pharmacological studies indicate that specific charged residues in TASK‐2 confer its pH‐sensing properties and that rare coding variants in KCNK5 may predispose individuals to renal and ventilatory dysfunction in certain clinical settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted role of KCNK5/TASK‐2 channels in pH sensing, cellular volume regulation, respiratory drive, and immune modulation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "María Isabel Niemeyer, L Pablo Cid, Gaspar Peña-Münzenmayer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Separate gating mechanisms mediate the regulation of K2P potassium channel TASK-2 by intra- and extracellular pH."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.107060"}], "href": "https://doi.org/10.1074/jbc.M110.107060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20351106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20351106"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michael J Morton, Abdulrahman Abohamed, Asipu Sivaprasadarao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "pH sensing in the two-pore domain K+ channel, TASK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0506870102"}], "href": "https://doi.org/10.1073/pnas.0506870102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16239344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16239344"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Baobin Li, Robert A Rietmeijer, Stephen G Brohawn "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for pH gating of the two-pore domain K"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " channel TASK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-020-2770-2"}], "href": "https://doi.org/10.1038/s41586-020-2770-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32999458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32999458"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sébastien L'Hoste, Mallorie Poet, Christophe Duranton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of TASK2 in the control of apoptotic volume decrease in proximal kidney cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M703933200"}], "href": "https://doi.org/10.1074/jbc.M703933200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17947235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17947235"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sheng Wang, Najate Benamer, Sébastien Zanella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2451-13.2013"}], "href": "https://doi.org/10.1523/JNEUROSCI.2451-13.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24107938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24107938"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shmuel Goldberg, Hanna Maria Ollila, Ling Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0168930"}], "href": "https://doi.org/10.1371/journal.pone.0168930"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28045995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28045995"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Stefan Bittner, Nicole Bobak, Alexander M Herrmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of K2P5.1 potassium channels in multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.22010"}], "href": "https://doi.org/10.1002/ana.22010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20582984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20582984"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nicole Bobak, Stefan Bittner, Joseph Andronic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamem.2011.04.013"}], "href": "https://doi.org/10.1016/j.bbamem.2011.04.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21575593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21575593"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dong Hoon Shin, Haiyue Lin, Haifeng Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIF-1α-mediated upregulation of TASK-2 K⁺ channels augments Ca²⁺ signaling in mouse B cells under hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1301829"}], "href": "https://doi.org/10.4049/jimmunol.1301829"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25305321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25305321"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "D Toncheva, M Mihailova-Hristova, R Vazharova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NGS nominated CELA1, HSPG2, and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/920723"}], "href": "https://doi.org/10.1155/2014/920723"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24949484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24949484"}]}]}]}
Synonyms	K2P5.1, TASK-2, KCNK5B, TASK2
Proteins	KCNK5_HUMAN
NCBI Gene ID	8645
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KCNK5 has 5,810 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for KCNK5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KCNK5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNK5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNK5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KCNK5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KCNK5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNK5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNK5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCNK5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCNK5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of KCNK5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCNK5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNK5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KCNK5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNK5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KCNK5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KCNK5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KCNK5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KCNK5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KCNK5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KCNK5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCNK5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KCNK5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KCNK5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KCNK5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with KCNK5 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KCNK5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KCNK5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving KCNK5 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KCNK5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KCNK5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KCNK5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KCNK5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KCNK5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KCNK5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNK5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KCNK5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KCNK5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with KCNK5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with KCNK5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNK5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with KCNK5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.