{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KCNMB2‐AS1 is a long non‐coding RNA that is significantly upregulated in several cancer types, including esophageal, bladder, and cervical cancers. In esophageal cancer, KCNMB2‐AS1 acts as an oncogenic RNA by binding to miR‑3194‑3p, which leads to the upregulation of glycogen phosphorylase L (PYGL) and the promotion of cell proliferation, invasion, migration, and stemness characteristics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In bladder cancer, elevated levels of KCNMB2‐AS1 have been shown to facilitate tumor progression. It mediates its effects by regulating the miR‑3194‑3p/SMAD5 signaling pathway, with loss‐of-function studies demonstrating that knockdown of KCNMB2‐AS1 inhibits cell growth, migration, invasion, and stemness"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In cervical cancer, overexpression of KCNMB2‐AS1 is associated with poor clinical outcomes, and its depletion leads to reduced cell proliferation and increased apoptosis, further supporting its role as an oncogenic driver."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies suggest that KCNMB2‐AS1 contributes to cancer development by functioning as a molecular sponge for miR‑3194‑3p and enhancing downstream oncogenic signaling. Its consistent upregulation and tumor‐promoting activities in multiple cancer types highlight KCNMB2‐AS1 as a promising biomarker and potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiwen Xu, Xiaoyan Liu, Xueting Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1973775"}], "href": "https://doi.org/10.1080/21655979.2021.1973775"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34516362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34516362"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yong-Sheng Chen, Yong-Peng Xu, Wen-Hua Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA KCNMB2-AS1 Promotes SMAD5 by Targeting miR-3194-3p to Induce Bladder Cancer Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.649778"}], "href": "https://doi.org/10.3389/fonc.2021.649778"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34026626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34026626"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianhua Zhu, Yan Huang, Yong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCNMB2-AS1 Promotes Bladder Cancer Progression Through Sponging miR-374a-3p to Upregulate S100A10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.655569"}], "href": "https://doi.org/10.3389/fgene.2021.655569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34367236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34367236"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yao Zhang, Dian Wang, Dan Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA KCNMB2-AS1 Stabilized by N"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-Methyladenosine Modification Promotes Cervical Cancer Growth Through Acting as a Competing Endogenous RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Transplant (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0963689720964382"}], "href": "https://doi.org/10.1177/0963689720964382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33028109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33028109"}]}]}]}