KCNQ5 Gene

HGNC Family	Ion channels
Name	potassium channel, voltage gated KQT-like subfamily Q, member 5
Description	This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KCNQ5, a subunit of the voltage‐gated Kv7 (KCNQ) family, plays diverse roles in regulating cellular excitability across both central and peripheral tissues. In the brain, KCNQ5 channels contribute to M‐type potassium currents that help control the afterhyperpolarization and firing properties of neurons, thereby supporting proper network synchronization. Inactivation or mutation of KCNQ5 has been linked to altered repolarization reserve and increased neuronal excitability, which can underlie developmental epilepsies, intellectual disability, and treatment‐resistant seizures."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " Moreover, in hypothalamic neuropeptide Y neurons, estrogen selectively upregulates KCNQ5 expression, suggesting that hormonal modulation of this channel may influence energy homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Outside the central nervous system, KCNQ5 is expressed in vascular and gastrointestinal smooth muscle, where it often assembles with other Kv7 subunits to form heteromeric channels that dampen excitability and thereby contribute to the regulation of vascular tone and motility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In the inner ear vestibular system, KCNQ5 localizes to postsynaptic structures and likely modulates synaptic transmission, a function that may influence hearing processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, these findings underscore the critical and multifaceted role of KCNQ5 channels in stabilizing membrane potential and modulating cellular excitability throughout the nervous system and peripheral tissues.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anastassios V Tzingounis, Matthias Heidenreich, Tatjana Kharkovets, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1004644107"}], "href": "https://doi.org/10.1073/pnas.1004644107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20534576"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20534576"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Anna Lehman, Samrat Thouta, Grazia M S Mancini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2017.05.016"}], "href": "https://doi.org/10.1016/j.ajhg.2017.05.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28669405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28669405"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rían W Manville, Maria Papanikolaou, Geoffrey W Abbott "}, {"type": "b", "children": [{"type": "t", "text": "Direct neurotransmitter activation of voltage-gated potassium channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-04266-w"}], "href": "https://doi.org/10.1038/s41467-018-04266-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29748663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29748663"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Henrik Sindal Jensen, Kirstine Callø, Thomas Jespersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res Mol Brain Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molbrainres.2005.05.007"}], "href": "https://doi.org/10.1016/j.molbrainres.2005.05.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15963599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15963599"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Pawel Fidzinski, Tatiana Korotkova, Matthias Heidenreich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7254"}], "href": "https://doi.org/10.1038/ncomms7254"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25649132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25649132"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Troy A Roepke, Jian Qiu, Arik W Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fasting and 17β-estradiol differentially modulate the M-current in neuropeptide Y neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1395-11.2011"}], "href": "https://doi.org/10.1523/JNEUROSCI.1395-11.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21849543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21849543"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shuk Yin M Yeung, Wienke Lange, Michael Schwake, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression profile and characterisation of a truncated KCNQ5 splice variant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.04.129"}], "href": "https://doi.org/10.1016/j.bbrc.2008.04.129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18457656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18457656"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Anna Oliveras, Meritxell Roura-Ferrer, Laura Solé, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.114.303801"}], "href": "https://doi.org/10.1161/ATVBAHA.114.303801"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24855057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24855057"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Guillermo Spitzmaul, Leonardo Tolosa, Beerend H J Winkelman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.433383"}], "href": "https://doi.org/10.1074/jbc.M112.433383"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23408425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23408425"}]}]}]}
Synonyms	MRD46, KV7.5
Proteins	KCNQ5_HUMAN
NCBI Gene ID	56479
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KCNQ5 has 7,411 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for KCNQ5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KCNQ5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNQ5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNQ5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KCNQ5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KCNQ5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KCNQ5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNQ5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving KCNQ5 protein from the Biocarta Pathways dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCNQ5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCNQ5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCNQ5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNQ5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNQ5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KCNQ5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KCNQ5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with KCNQ5 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing KCNQ5 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KCNQ5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KCNQ5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KCNQ5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing KCNQ5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KCNQ5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KCNQ5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCNQ5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KCNQ5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KCNQ5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KCNQ5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with KCNQ5 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KCNQ5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving KCNQ5 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with KCNQ5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KCNQ5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KCNQ5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KCNQ5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KCNQ5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KCNQ5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for KCNQ5 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KCNQ5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNQ5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KCNQ5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KCNQ5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.