{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KCNQ5‑IT1 is a long non‑coding RNA that has been found to be significantly upregulated in pathological conditions. In rheumatoid arthritis (RA), RNA‑sequencing of synovial tissues and subsequent RT‑qPCR validation revealed increased expression levels of KCNQ5‑IT1 in patients compared to healthy controls, suggesting that it may be involved in the inflammatory and immune processes that characterize RA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, a separate systematic review focusing on leukemia reported that KCNQ5‑IT1 is among a group of lncRNAs consistently dysregulated—specifically upregulated—in patient samples, emphasizing its potential relevance in the pathogenesis or progression of different leukemia subtypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although the precise mechanistic role of KCNQ5‑IT1 has not been fully elucidated in either disease context, its consistent overexpression across these studies points to a possible contributory role in modulating disease-specific cellular pathways.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xuemei Piao, Jieru Zhou, Jiandong Hu "}, {"type": "b", "children": [{"type": "t", "text": "Role of RP11-83J16.1, a novel long non-coding RNA, in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2020)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32355550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32355550"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cristine Dieter, Eloir Dutra Lourenco, Natália Emerim Lemos "}, {"type": "b", "children": [{"type": "t", "text": "Association of long non-coding RNA and leukemia: A systematic review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2020.144405"}], "href": "https://doi.org/10.1016/j.gene.2020.144405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32014562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32014562"}]}]}]}