{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A recent study on hypertensive nephropathy (HTN) identified multiple differentially expressed RNAs, among which the long non-coding RNA (lncRNA) KCTD21‐AS1 emerged as a central hub in the competing endogenous RNA (ceRNA) regulatory network (1). In this context, KCTD21‐AS1 is proposed to act as a key regulator that may influence the balance between mRNAs and microRNAs involved in various biological processes and pathways. These processes include fatty acid beta‑oxidation, unfolded protein response, and transmembrane transport, while the network analysis further implicated metabolic and signaling routes such as insulin signaling and glycine, serine and threonine metabolism. Although other lncRNAs (e.g., LINC00470 and SNHG14) were also highlighted as hub nodes and potential biomarkers, the prominent placement of KCTD21‐AS1 within the ceRNA framework suggests that it could play an important role in mediating molecular interactions that underlie the development and progression of HTN. Further elucidation of KCTD21‐AS1’s regulatory mechanisms may provide valuable insights into its function as a biomarker and potential therapeutic target in hypertensive renal injury."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhen Wang, Zhongjie Liu, Yingxia Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of biomarkers and pathways in hypertensive nephropathy based on the ceRNA regulatory network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Nephrol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12882-020-02142-8"}], "href": "https://doi.org/10.1186/s12882-020-02142-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33176720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33176720"}]}]}]}