{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KDM4A‐AS1 is an oncogenic long non‐coding RNA that has been implicated in the progression and poor prognosis of certain cancers. In hepatocellular carcinoma (HCC), KDM4A‐AS1 is aberrantly overexpressed and forms part of lncRNA prognostic signatures. It promotes tumor cell proliferation, migration, invasion, and metastasis by acting as a competitive endogenous RNA (ceRNA): it sponges miR‑411‑5p to relieve its repression on KPNA2, thereby activating the AKT pathway and engaging in a feedback loop with hypoxia‑inducible factor 1α (HIF‑1α) under hypoxic conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, in castration‐resistant prostate cancer (CRPC), KDM4A‑AS1 functions as a tumor promoter by binding to the N‐terminal domain of the androgen receptor (AR) and its splice variants. This interaction stabilizes the USP14–AR/AR‑Vs complex, thereby enhancing deubiquitination and protecting AR/AR‑Vs from proteasomal degradation. Such stabilization facilitates tumor growth and contributes to resistance against antiandrogen therapies like enzalutamide."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, KDM4A‐AS1 mediates cancer progression via distinct molecular mechanisms depending on the tumor context, underscoring its potential as a prognostic biomarker and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Benyuan Deng, Min Yang, Ming Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development and validation of 9-long Non-coding RNA signature to predicting survival in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000020422"}], "href": "https://doi.org/10.1097/MD.0000000000020422"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32481346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32481346"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tianxiang Chen, Runkun Liu, Yongshen Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIF-1α-activated long non-coding RNA KDM4A-AS1 promotes hepatocellular carcinoma progression via the miR-411-5p/KPNA2/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04449-2"}], "href": "https://doi.org/10.1038/s41419-021-04449-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34903711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34903711"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lu Yin, Liuzhi Zhou, Shiqi Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Classification of Hepatocellular Carcinoma Based on N6-Methylandenosine-Related lncRNAs Profiling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Mol Biosci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fmolb.2022.807418"}], "href": "https://doi.org/10.3389/fmolb.2022.807418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35187083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35187083"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Boya Zhang, Mingpeng Zhang, Yanjie Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting KDM4A-AS1 represses AR/AR-Vs deubiquitination and enhances enzalutamide response in CRPC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-02103-x"}], "href": "https://doi.org/10.1038/s41388-021-02103-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34759344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34759344"}]}]}]}