{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent study focused on identifying stemness‐related genes in renal clear cell carcinoma (ccRCC), a prognostic gene signature was developed using machine learning algorithms applied to TCGA data (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " The signature comprised several genes—including AC010973.2, RNU6-125P, AP001209.2, Z98885.1, KDM5C-IT1, and AL021368.3—with each gene potentially reflecting aspects of tumor stemness that contribute to disease progression and overall patient survival in ccRCC. Although the study prioritized AC010973.2 for further experimental validation—demonstrating its high expression in ccRCC tissues and its role in promoting cell proliferation—the inclusion of KDM5C-IT1 in the multi-gene model suggests that it may also be implicated in the regulation of tumor stemness and, by extension, in the clinical outcomes of ccRCC patients. Consequently, while the direct functional mechanisms of KDM5C-IT1 were not independently interrogated in this investigation, its identification as a component of the prognostic signature highlights its potential importance as a biomarker for ccRCC stemness and a candidate for future functional studies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yingqing Liu, Jiawei Wang, Lin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AC010973.2 promotes cell proliferation and is one of six stemness-related genes that predict overall survival of renal clear cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-07070-1"}], "href": "https://doi.org/10.1038/s41598-022-07070-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35277527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35277527"}]}]}]}