{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSeveral of the provided studies describe seminal molecular events in reproductive biology. Two abstracts report on the roles of ADAM proteins in the mouse testis and epididymis, where distinct isoforms (ADAM1a and ADAM1b) contribute to the proper maturation and function of sperm. ADAM1a, confined to the endoplasmic reticulum of testicular germ cells, forms a complex with ADAM2 to ensure the surface expression of ADAM3—a key protein for sperm migration, cumulus cell dispersal, and binding to the zona pellucida—thus emphasizing its crucial role in fertilization processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, a set of studies focused on a long noncoding RNA designated JHDM1D-AS1—which appears to be functionally analogous or related to KDM7A-DT—and its protective roles in diverse cellular contexts. In periodontal ligament stem cells exposed to oxidative stress, JHDM1D-AS1 is rapidly downregulated, and its diminished expression is associated with increased apoptosis. Mechanistically, this lncRNA exerts an anti-apoptotic influence by inhibiting DNAJC10, thereby modulating downstream factors such as Bcl-2 and eIF2α phosphorylation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in a neuronal model of Parkinson’s disease, overexpression of JHDM1D-AS1 counteracts MPP⁺-induced injury by acting as a competing endogenous RNA—it sequesters miR-134-5p to upregulate the expression of its target gene PIK3R3, thus alleviating neuronal apoptosis, inflammation, and oxidative stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In parallel, investigations in monocytes reveal that JHDM1D-AS1 is inducible via NF-κB activation upon exposure to bacterial products or Toll-like receptor ligands, and it functions as an anti-inflammatory mediator by reducing the transcription of proinflammatory cytokines."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Lastly, an additional study on the osteogenic differentiation of periodontal ligament cells presents another biological context, although it does not specifically elucidate a function for KDM7A-DT."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hitoshi Nishimura, Ekyune Kim, Tomoko Nakanishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M314249200"}], "href": "https://doi.org/10.1074/jbc.M314249200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15194697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15194697"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ekyune Kim, Hitoshi Nishimura, Tadashi Baba "}, {"type": "b", "children": [{"type": "t", "text": "Differential localization of ADAM1a and ADAM1b in the endoplasmic reticulum of testicular germ cells and on the surface of epididymal sperm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)00588-6"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "00588-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12711316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12711316"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bai Shi, Bingyi Shao, Chonshi Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of JHDM1D-AS1 protects PDLSCs from H"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "O"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "-induced apoptosis by decreasing DNAJC10 via phosphorylation of eIF2α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2019.06.018"}], "href": "https://doi.org/10.1016/j.biochi.2019.06.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31276733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31276733"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Cuihui Wang, Hongying Zhang, Ji Li "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA JHDM1D-AS1 Suppresses MPP + -Induced Neuronal Injury in Parkinson's Disease via miR-134-5p/PIK3R3 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurotox Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12640-021-00437-8"}], "href": "https://doi.org/10.1007/s12640-021-00437-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34773593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34773593"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Erik Malmström, Hina N Khan, Cornelis van 't Veer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Long Non-Coding Antisense RNA JHDM1D-AS1 Regulates Inflammatory Responses in Human Monocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Infect Microbiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcimb.2022.934313"}], "href": "https://doi.org/10.3389/fcimb.2022.934313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35903199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35903199"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaohuan Zhong, Huixin Wang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA JHDM1D-AS1 promotes osteogenic differentiation of periodontal ligament cells by targeting miR-532-5p to activate IGF1R signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Periodontal Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jre.13209"}], "href": "https://doi.org/10.1111/jre.13209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37950511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37950511"}]}]}]}