{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent research on competing endogenous RNA (ceRNA) networks in cancer has revealed that noncoding RNA‐mediated regulation plays a pivotal role in controlling gene expression and tumor cell behavior. In a study of breast cancer, the long noncoding RNA LINC00665 was shown to promote cell survival and metastasis by “sponging” miR‑641, which in turn targets several mRNAs. Among these potential downstream targets, KHDC4 was identified by quantitative PCR alongside other candidates (e.g., SRCAP, SIKE1, NADK, and HSPG2)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although further functional validation was performed for SRCAP – establishing its role in counteracting the antiproliferative and anti‑invasive effects induced by miR‑641 – KHDC4’s inclusion as a putative target suggests that it may also participate in the regulation of oncogenic pathways in breast cancer. \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Notably, KHDC4 belongs to the family of KH domain‐containing proteins, which are well documented for their roles in RNA binding and the regulation of pre‑mRNA processing events such as splicing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " This connection reinforces the possibility that KHDC4 might contribute to fine‑tuning post‑transcriptional gene regulation in neoplastic cells. Furthermore, the broader landscape of noncoding RNA research demonstrates that deregulated RNA networks—including those involving small nucleolar RNAs and circular RNAs—can modulate diverse cancer cell functions, from proliferation to invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, although the direct functional consequences of KHDC4 modulation in breast cancer remain to be fully elucidated, its identification as a candidate target within a miR‑641–mediated ceRNA regulatory axis positions KHDC4 as a promising subject for further investigation. Clarifying its role may not only extend our understanding of RNA‑binding protein function in cancer but also eventually contribute to the development of novel prognostic biomarkers or therapeutic targets.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wen Cao, Xiaojing Liu, Weijia Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00665 sponges miR-641 to promote the progression of breast cancer by targeting the SNF2-related CREBBP activator protein (SRCAP)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2031402"}], "href": "https://doi.org/10.1080/21655979.2022.2031402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35152838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35152838"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marlies Löscher, Markus Schosserer, Eric Dausse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0047497"}], "href": "https://doi.org/10.1371/journal.pone.0047497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23144703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23144703"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kaiissar Mannoor, Jipei Liao, Feng Jiang "}, {"type": "b", "children": [{"type": "t", "text": "Small nucleolar RNAs in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbcan.2012.03.005"}], "href": "https://doi.org/10.1016/j.bbcan.2012.03.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22498252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22498252"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "L S Kristensen, T B Hansen, M T Venø, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNAs in cancer: opportunities and challenges in the field."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2017.361"}], "href": "https://doi.org/10.1038/onc.2017.361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28991235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28991235"}]}]}]}