{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted an important role for long noncoding RNAs in modulating airway cell function and inflammation in respiratory diseases. Although KIAA1614‑AS1 is not discussed in detail in these reports, its inclusion among the panel of dysregulated lncRNAs suggests that it may act in a similar regulatory capacity. In airway smooth muscle cells, treatment with a corticosteroid and growth factors resulted in changes in lncRNA expression that were associated with regulation of the actin cytoskeleton and inflammatory responses. In this context, several lncRNAs appear to function as competing endogenous RNAs—or “sponges”—that sequester specific microRNAs and thereby modulate the expression of target mRNAs involved in cell proliferation and cytoskeletal remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Likewise, analysis of peripheral blood mononuclear cells from chronic obstructive pulmonary disease patients revealed a distinct lncRNA expression profile, supporting the notion that these transcripts contribute to immune regulation and chronic inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although direct experimental data for KIAA1614‑AS1 remain to be established, its dysregulation in similar experimental settings implies that it could participate in these key regulatory networks, influencing airway remodeling and inflammatory processes. Further investigation is therefore warranted to clarify its precise function in respiratory pathophysiology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mark M Perry, Eleni Tsitsiou, Philip J Austin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of non-coding RNAs in maintaining primary airway smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Respir Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1465-9921-15-58"}], "href": "https://doi.org/10.1186/1465-9921-15-58"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24886442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24886442"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoyan Qu, Xiaomin Dang, Weijia Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNAs and mRNA Regulation in Peripheral Blood Mononuclear Cells of Patients with Chronic Obstructive Pulmonary Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mediators Inflamm (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2018/7501851"}], "href": "https://doi.org/10.1155/2018/7501851"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29725270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29725270"}]}]}]}