KIF23 Gene

HGNC Family	Kinesins (KIF)
Name	kinesin family member 23
Description	The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KIF23, also known as MKLP1 or CHO1, is a mitotic kinesin motor protein that plays a critical role in the final stages of cell division. It is essential for the organization and stabilization of the central spindle and midbody, thereby ensuring the formation of proper intercellular bridges and successful cytokinetic abscission. In normal cells, tightly controlled KIF23 expression and localization are required for an accurate G2/M transition and the faithful separation of daughter cells. Transcriptional negative regulation via the p53–p21–DREAM–CDE/CHR pathway has been shown to modulate KIF23 levels and prevent unscheduled cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, hormone-regulated mechanisms in cancer cells also lead to the upregulation of KIF23, which in turn is associated with enhanced cell proliferation and poor clinical outcomes in breast cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, KIF23 functions through its interactions with other key regulators of cytokinesis such as Polo-like kinase 1 (Plk1) and the inner centromere protein (INCENP), which are required for its proper localization at the spindle midzone and for executing cleavage furrow ingression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Its role is further underscored during germ cell division, where KIF23 is a major component of the intercellular bridges in both male and female embryonic cells, a feature that is essential for maintaining normal cytokinesis during gametogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In pathological contexts, such as in a rare case of a KLF1-null human, KIF23 was pinpointed as one of the pivotal target genes required for proper cytokinesis, and its misregulation can contribute to the emergence of polyploidy and genomic instability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in glioma, suppression of KIF23 expression has been demonstrated to markedly inhibit tumor cell proliferation, positioning it as an attractive candidate for therapeutic intervention in malignant tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings establish KIF23 as a central regulator of cytokinesis whose precise control is crucial for maintaining genomic stability. Its dysregulation disrupts proper cell division, thereby contributing to tumor development and progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Martin Fischer, Marianne Quaas, Lydia Steiner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv927"}], "href": "https://doi.org/10.1093/nar/gkv927"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26384566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26384566"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "June X Zou, Zhijian Duan, Junjian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-13-0459"}], "href": "https://doi.org/10.1158/1541-7786.MCR-13-0459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24391143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24391143"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoqi Liu, Tianhua Zhou, Ryoko Kuriyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01173"}], "href": "https://doi.org/10.1242/jcs.01173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15199097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15199097"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michael P Greenbaum, Naoki Iwamori, Julio E Agno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.108.070649"}], "href": "https://doi.org/10.1095/biolreprod.108.070649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19020301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19020301"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Graham W Magor, Michael R Tallack, Kevin R Gillinder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2014-08-590968"}], "href": "https://doi.org/10.1182/blood-2014-08-590968"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25724378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25724378"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Satoshi Takahashi, Noemi Fusaki, Shigeki Ohta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of KIF23 suppresses glioma proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-011-0706-2"}], "href": "https://doi.org/10.1007/s11060-011-0706-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21904957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21904957"}]}]}]}
Synonyms	MKLP1, MKLP-1, CHO1, KNSL5
Proteins	KIF23_HUMAN
NCBI Gene ID	9493
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KIF23 has 9,324 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 119 datasets.

Click the + buttons to view associations for KIF23 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KIF23 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF23 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF23 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KIF23 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KIF23 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF23 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF23 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KIF23 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KIF23 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KIF23 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF23 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KIF23 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KIF23 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIF23 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KIF23 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KIF23 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KIF23 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KIF23 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KIF23 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KIF23 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KIF23 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KIF23 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing KIF23 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KIF23 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KIF23 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KIF23 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KIF23 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KIF23 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate KIF23 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving KIF23 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KIF23 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KIF23 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KIF23 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KIF23 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KIF23 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIF23 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KIF23 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KIF23 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with KIF23 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with KIF23 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF23 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.