KIF5B Gene

HGNC Family	Kinesins (KIF)
Name	kinesin family member 5B
Description	Enables identical protein binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including natural killer cell mediated cytotoxicity; positive regulation of protein localization to plasma membrane; and vesicle transport along microtubule. Located in centriolar satellite; cytosol; and vesicle. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KIF5B, a member of the conventional kinesin‐1 family, plays multifaceted roles in both normal cellular transport and disease pathogenesis. As a molecular motor, KIF5B drives anterograde, microtubule‐dependent trafficking of diverse cargos. Its activity is essential for directing lysosomal movement along perinuclear, acetylated microtubule tracks"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and for mediating the insulin‐stimulated translocation of GLUT4‐containing vesicles to the plasma membrane in adipocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In polarized epithelial cells, KIF5B is crucial for post-Golgi transport of apical proteins, thereby contributing to the maintenance of cell polarity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its classical transport functions, KIF5B is implicated in regulating stress granule dynamics; impairment of its activity delays stress granule dissolution, indicating that balanced anterograde transport is key for proper mRNP turnover during cellular stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, during HIV-1 infection, KIF5B contributes to viral uncoating and the subsequent nuclear import of viral genomes by mediating relocalization of nuclear pore components such as Nup358, a process essential for productive infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n KIF5B also functions as an oncogenic fusion partner. Recurrent fusions of KIF5B with receptor tyrosine kinases—most notably RET in lung adenocarcinomas"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "—and with PDGFRA in chronic eosinophilic leukemia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "lead to aberrant kinase activation that promotes tumorigenesis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n The regulation and specificity of KIF5B-mediated transport is further refined by interactions with adaptor proteins. For instance, MAP7 family members enhance the motor’s microtubule association and processivity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", while protrudin facilitates its role in vesicular transport within neurons."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In neuronal contexts, selective docking of KIF5B (along with its homolog KIF5C) by RanBP2 underscores its involvement in specialized transport processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight that KIF5B is not only central to the coordinated intracellular trafficking that sustains normal cell function but also plays key roles in pathological processes—ranging from cancer-driving gene fusions to the manipulation of host cell functions during viral infection.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carlos M Guardia, Ginny G Farías, Rui Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.10.062"}], "href": "https://doi.org/10.1016/j.celrep.2016.10.062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27851960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27851960"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sabina Semiz, Jin G Park, Sarah M C Nicoloro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg237"}], "href": "https://doi.org/10.1093/emboj/cdg237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12743033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12743033"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fanny Jaulin, Xiaoxiao Xue, Enrique Rodriguez-Boulan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2007.08.001"}], "href": "https://doi.org/10.1016/j.devcel.2007.08.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17925227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17925227"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mariela Loschi, Claudia C Leishman, Neda Berardone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynein and kinesin regulate stress-granule and P-body dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.051383"}], "href": "https://doi.org/10.1242/jcs.051383"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19825938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19825938"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zana Lukic, Adarsh Dharan, Thomas Fricke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIV-1 uncoating is facilitated by dynein and kinesin 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02219-14"}], "href": "https://doi.org/10.1128/JVI.02219-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25231297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25231297"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Adarsh Dharan, Sarah Talley, Abhishek Tripathi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1005700"}], "href": "https://doi.org/10.1371/journal.ppat.1005700"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27327622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27327622"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kengo Takeuchi, Manabu Soda, Yuki Togashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RET, ROS1 and ALK fusions in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2658"}], "href": "https://doi.org/10.1038/nm.2658"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22327623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22327623"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Doron Lipson, Marzia Capelletti, Roman Yelensky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2673"}], "href": "https://doi.org/10.1038/nm.2673"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22327622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22327622"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Takashi Kohno, Hitoshi Ichikawa, Yasushi Totoki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIF5B-RET fusions in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2644"}], "href": "https://doi.org/10.1038/nm.2644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22327624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22327624"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rui Wang, Haichuan Hu, Yunjian Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2012.44.1477"}], "href": "https://doi.org/10.1200/JCO.2012.44.1477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23150706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23150706"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "J Score, C Curtis, K Waghorn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.leu.2404154"}], "href": "https://doi.org/10.1038/sj.leu.2404154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16498388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16498388"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Peter Jan Hooikaas, Maud Martin, Tobias Mühlethaler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAP7 family proteins regulate kinesin-1 recruitment and activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201808065"}], "href": "https://doi.org/10.1083/jcb.201808065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30770434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30770434"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Fumiko Matsuzaki, Michiko Shirane, Masaki Matsumoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E11-01-0068"}], "href": "https://doi.org/10.1091/mbc.E11-01-0068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21976701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21976701"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Y Cai, B B Singh, A Aslanukov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M104514200"}], "href": "https://doi.org/10.1074/jbc.M104514200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11553612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11553612"}]}]}]}
Synonyms	UKHC, KNS, KINH, KNS1, HEL-S-61
Proteins	KINH_HUMAN
NCBI Gene ID	3799
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KIF5B has 13,187 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 140 datasets.

Click the + buttons to view associations for KIF5B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KIF5B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by KIF5B gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF5B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF5B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KIF5B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KIF5B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KIF5B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF5B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF5B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KIF5B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KIF5B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of KIF5B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KIF5B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF5B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KIF5B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KIF5B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIF5B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KIF5B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KIF5B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with KIF5B gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of KIF5B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing KIF5B protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KIF5B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KIF5B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KIF5B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KIF5B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing KIF5B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KIF5B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KIF5B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing KIF5B protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KIF5B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KIF5B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KIF5B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KIF5B gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with KIF5B gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KIF5B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for KIF5B protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KIF5B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KIF5B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KIF5B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KIF5B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.