{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KIF9‐AS1 is a long noncoding RNA whose aberrant expression has been implicated in both inflammatory and malignant disorders. In inflammatory bowel disease (IBD), increased levels of KIF9‐AS1 have been observed in patient tissue and plasma samples, suggesting its potential as a diagnostic biomarker. Functional studies in IBD models further reveal that KIF9‐AS1 can promote colonic epithelial cell apoptosis and inflammation via modulation of the miR‑148a‑3p/SOCS3 axis, thereby contributing to disease progression (1,3). In the context of cancer, KIF9‐AS1 appears to exert oncogenic functions. In renal cell carcinoma, its overexpression is associated with enhanced cell viability and likely drug resistance (2), while in nasopharyngeal carcinoma elevated KIF9‐AS1 levels facilitate tumor progression by targeting miR‑16, with higher expression correlating with advanced clinical stage and poorer prognosis (4). Moreover, KIF9‐AS1 has been incorporated into a multi‐lncRNA signature panel in ovarian cancer studies, indicating its potential utility in monitoring therapeutic response to agents such as ivermectin (5). Collectively, these findings highlight KIF9‐AS1 as both a promising biomarker and a functional mediator in the pathogenesis of IBD and various cancers, presenting opportunities for its future exploitation as a therapeutic target."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sen Wang, Yong Hou, Weiping Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.8118"}], "href": "https://doi.org/10.3892/mmr.2017.8118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29207070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29207070"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yichen Jin, Ru Huang, Yanfu Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "KIF9-AS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Regulates Transforming Growth Factor-β and Autophagy Signaling to Enhance Renal Cell Carcinoma Chemoresistance via microRNA-497-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2020.5453"}], "href": "https://doi.org/10.1089/dna.2020.5453"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32343913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32343913"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jun Yao, Ruoyu Gao, Minghan Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA KIF9-AS1 promotes cell apoptosis by targeting the microRNA-148a-3p/suppressor of cytokine signaling axis in inflammatory bowel disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Gastroenterol Hepatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MEG.0000000000002309"}], "href": "https://doi.org/10.1097/MEG.0000000000002309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34750325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34750325"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Huizeng You, Shuyong Wang, Sa Yu "}, {"type": "b", "children": [{"type": "t", "text": "KIF9-AS1 promotes nasopharyngeal carcinoma progression by suppressing miR-16."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2020.12104"}], "href": "https://doi.org/10.3892/ol.2020.12104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32973955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32973955"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Na Li, Xianquan Zhan "}, {"type": "b", "children": [{"type": "t", "text": "Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EPMA J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13167-020-00209-y"}], "href": "https://doi.org/10.1007/s13167-020-00209-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32549918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32549918"}]}]}]}