{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KIF‐binding protein (KBP), encoded by the KIAA1279 gene, functions as a selective regulator of kinesin motor proteins. By binding directly to the motor domains of specific kinesins, KBP prevents their association with microtubules, thereby modulating the activity of motors involved in vesicular transport and in microtubule dynamics in neuronal cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In developing neurons, this inhibitory role is crucial for controlling synaptic vesicle transport and ensuring proper axonal growth, while in embryonic stem cells, regulated degradation of KBP is essential to prevent unscheduled increases in mitochondrial biogenesis and oxidative stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " During neural development, loss‐of‐function mutations in KIAA1279 cause Goldberg–Shprintzen syndrome—a disorder marked by intellectual disability, microcephaly, Hirschsprung disease, and other neuronal abnormalities—underscoring KBP’s vital role in both central and peripheral nervous system development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, KBP functions as a “protein buffer” during mitosis by reducing the activities of kinesins such as KIF18A and KIF15, thereby preventing excessive microtubule binding that would otherwise disrupt proper chromosome alignment and spindle dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " KBP also interacts with other kinesin family members, including KIF1Bα and the newly identified KLP6, to regulate mitochondrial morphology and transport in neuronal and other cell types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, its interaction with kinesin partners has been implicated in specialized processes such as spermatid elongation during spermatogenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "and may also have prognostic or driver roles in malignancies like neuroblastoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Josta T Kevenaar, Sarah Bianchi, Myrrhe van Spronsen, et al. 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