KIR2DS3 Gene

HGNC Family Immunoglobulin superfamily domain containing, Killer cell immunoglobulin-like receptors (KIR)
Name killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
Description Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several `framework` genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nKIR2DS3 is an activating receptor gene expressed on natural killer (NK) cells that plays a modulatory role in innate immune responses during viral infections. In a study of hepatitis C virus (HCV) infection in a highly homogeneous Irish cohort, it was observed that the prevalence of KIR2DS3 was significantly higher in patients with chronic infection compared with those who spontaneously resolved the virus. This association suggests that the engagement of KIR2DS3 on NK cells may alter their functional activity in a way that predisposes individuals to an impaired antiviral response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nDissection of the genetic factors revealed that the risk conveyed by KIR2DS3 is further amplified when present in combination with specific alleles in the interferon‐lambda (IL28B) locus. The synergistic interaction between KIR2DS3 and the IL28B “T” allele indicates that this receptor might affect the balance between proinflammatory and antiviral cytokine responses, thereby contributing to the failure to clear HCV effectively."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nCollectively, these findings imply that KIR2DS3 serves as a crucial immunogenetic factor that can influence the trajectory of HCV infection by modulating NK cell–mediated immune responses. The enhanced expression or functional engagement of KIR2DS3 may compromise the early innate immune response, favoring the establishment of chronic infection and highlighting its potential utility as a prognostic marker or therapeutic target in HCV management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Megan M Dring, Maria H Morrison, Brian P McSharry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1016358108"}], "href": "https://doi.org/10.1073/pnas.1016358108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21402922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21402922"}]}]}]}
Synonyms NKAT7
Proteins KI2S3_HUMAN
NCBI Gene ID 3808
API
Download Associations
Predicted Functions View KIR2DS3's ARCHS4 Predicted Functions.
Co-expressed Genes View KIR2DS3's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View KIR2DS3's ARCHS4 Predicted Functions.

Functional Associations

KIR2DS3 has 379 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 24 datasets.

Click the + buttons to view associations for KIR2DS3 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of KIR2DS3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of KIR2DS3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIR2DS3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of KIR2DS3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of KIR2DS3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
DisGeNET Gene-Disease Associations diseases associated with KIR2DS3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with KIR2DS3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
GAD Gene-Disease Associations diseases associated with KIR2DS3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with KIR2DS3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of KIR2DS3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with KIR2DS3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of KIR2DS3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of KIR2DS3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of KIR2DS3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GO Biological Process Annotations 2015 biological processes involving KIR2DS3 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving KIR2DS3 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Cellular Component Annotations 2015 cellular components containing KIR2DS3 protein from the curated GO Cellular Component Annotations 2015 dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with KIR2DS3 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for KIR2DS3 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of KIR2DS3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEGG Pathways pathways involving KIR2DS3 protein from the KEGG Pathways dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for KIR2DS3 from the Pathway Commons Protein-Protein Interactions dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with KIR2DS3 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of KIR2DS3 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.