KIR2DS3 Gene

HGNC Family	Immunoglobulin superfamily domain containing, Killer cell immunoglobulin-like receptors (KIR)
Name	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
Description	Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Synonyms	NKAT7
Proteins	KI2S3_HUMAN
NCBI Gene ID	3808
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KIR2DS3 has 345 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 20 datasets.

Click the + buttons to view associations for KIR2DS3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome

KIR2DS3 Gene

Functional Associations

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Funding

	Dataset	Summary
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KIR2DS3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KIR2DS3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CHEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIR2DS3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	CHEA Transcription Factor Targets	transcription factors binding the promoter of KIR2DS3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	GAD Gene-Disease Associations	diseases associated with KIR2DS3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with KIR2DS3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KIR2DS3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with KIR2DS3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of KIR2DS3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of KIR2DS3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of KIR2DS3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GO Biological Process Annotations	biological processes involving KIR2DS3 gene from the curated GO Biological Process Annotations dataset.
	GO Cellular Component Annotations	cellular components containing KIR2DS3 protein from the curated GO Cellular Component Annotations dataset.
	HuGE Navigator Gene-Phenotype Associations	phenotypes associated with KIR2DS3 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for KIR2DS3 protein from the InterPro Predicted Protein Domain Annotations dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of KIR2DS3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	KEGG Pathways	pathways involving KIR2DS3 protein from the KEGG Pathways dataset.
	Pathway Commons Protein-Protein Interactions	interacting proteins for KIR2DS3 from the Pathway Commons Protein-Protein Interactions dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of KIR2DS3 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
	TRANSFAC Predicted Transcription Factor Targets	transcription factors regulating expression of KIR2DS3 gene predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.