| HGNC Family | Killer cell immunoglobulin-like receptors (KIR), CD molecules (CD), Immunoglobulin superfamily domain containing |
| Name | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 |
| Description | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several `framework` genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nKIR2DS5 is an activating natural killer cell receptor expressed on discrete NK‐cell subsets that, upon engagement, is capable of triggering cytotoxicity and the release of cytokines. Functional studies have demonstrated that KIR2DS5 signals through its association with the adaptor molecule DAP12, thereby transducing activation signals that contribute to NK‐cell effector functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlthough many KIR receptors are known to recognize specific HLA class I ligands, binding assays with a soluble KIR2DS5-Fc fusion protein have failed to detect appreciable interactions with cells expressing a range of HLA-C alleles. This finding raises the possibility that KIR2DS5 either requires the presence of specific peptide or other cofactors to mediate ligand recognition or that it interacts with yet-to-be-defined ligands. In clinical settings, the presence of KIR2DS5 has been associated with improved outcomes following hematopoietic stem cell transplantation, and studies show that its gene is highly polymorphic with considerable variation in frequency across different populations, suggesting that its contribution to immune responsiveness may be shaped by genetic diversity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mariella Della Chiesa, Elisa Romeo, Michela Falco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200838434"}], "href": "https://doi.org/10.1002/eji.200838434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18624290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18624290"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Izabela Nowak, Edyta Majorczyk, Andrzej Wiśniewski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Does the KIR2DS5 gene protect from some human diseases?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0012381"}], "href": "https://doi.org/10.1371/journal.pone.0012381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20865034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20865034"}]}]}]}
|
| Synonyms | CD158G, NKAT9 |
| Proteins | KI2S5_HUMAN |
| NCBI Gene ID | 3810 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
KIR2DS5 has 500 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 25 datasets.
Click the + buttons to view associations for KIR2DS5 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by KIR2DS5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of KIR2DS5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of KIR2DS5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIR2DS5 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of KIR2DS5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with KIR2DS5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| GAD Gene-Disease Associations | diseases associated with KIR2DS5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with KIR2DS5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of KIR2DS5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with KIR2DS5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of KIR2DS5 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of KIR2DS5 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of KIR2DS5 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of KIR2DS5 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by KIR2DS5 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with KIR2DS5 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of KIR2DS5 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving KIR2DS5 protein from the KEGG Pathways dataset. | |
| KEGG Pathways 2026 | pathways involving KIR2DS5 protein from the KEGG Pathways 2026 dataset. | |
| Reactome Pathways 2014 | pathways involving KIR2DS5 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving KIR2DS5 protein from the Reactome Pathways 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of KIR2DS5 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of KIR2DS5 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of KIR2DS5 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of KIR2DS5 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
