KIR3DP1 Gene

HGNC Family CD molecules (CD), Immunoglobulin superfamily domain containing, Killer cell immunoglobulin-like receptors (KIR)
Name killer cell immunoglobulin-like receptor, three domains, pseudogene 1
Description Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several `framework` genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the `framework` loci that is present on all haplotypes. This gene is considered to be a pseudogene based on the absence of transcription and it lacks several functional domains compared to other killer cell immunoglobulin-like receptors. A rare haplotype, the result of a recombinantion event, has two copies of this gene, one of which may encode a secreted protein. (PMID: 15580659)[provided by RefSeq, Mar 2011]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA broad spectrum of studies has recently delineated the molecular circuitry that underpins cellular defenses against injury, stress, and inflammation. Several investigations describe how the transcription factor Nrf2 coordinates antioxidant and detoxification programs in response to electrophilic and oxidative insults, and how its regulation—via cytosolic sequestration by Keap1 and through non‐canonical mechanisms such as autophagy mediated by p62 and its KEAP1‐interacting region (KIR)—ensures homeostasis in settings as diverse as cancer, neurodegeneration, and sepsis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": " In parallel, a number of reports focus on proinflammatory cytokine networks—particularly those involving IL‑17, IL‑23, and related mediators—that shape immune responses in autoimmunity, host–pathogen interactions, and tissue repair."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "19"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " Additional studies extend these themes by examining the roles of apoptotic regulators, microRNA circuits, and stem/progenitor cell populations that collectively modulate stress responses and tissue integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, however, none of these studies provide any evidence or discussion regarding the function of KIR3DP1. While motifs designated “KIR” (as in the KEAP1‑interacting region of p62) play pivotal roles in modulating the Nrf2 pathway, and various immunological and stress‐responsive genes are described in these reports, there is no mention of the killer‐cell immunoglobulin‐like receptor 3D pseudogene 1 (KIR3DP1) or any functional attributes attributed to it. Thus, based on the literature surveyed herein"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}, {"type": "fg_fs", "start_ref": "13", "end_ref": "15"}, {"type": "fg_f", "ref": "27"}, {"type": "fg_fs", "start_ref": "16", "end_ref": "19"}, {"type": "fg_fs", "start_ref": "4", "end_ref": "12"}, {"type": "fg_f", "ref": "24"}, {"type": "fg_f", "ref": "22"}, {"type": "fg_f", "ref": "20"}, {"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": "no role for KIR3DP1 can be inferred. In summary, while the curated body of literature illuminates multiple stress‐ and immune‐responsive processes across a range of contexts, the function of KIR3DP1 remains unaddressed.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Truyen Nguyen, Paul Nioi, Cecil B Pickett "}, {"type": "b", "children": [{"type": "t", "text": "The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.R900010200"}], "href": "https://doi.org/10.1074/jbc.R900010200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19182219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19182219"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri, et al. 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Synonyms KIR48, KIR3DS2P, CD158C, KIR2DS6, KIRX
Proteins KI3P1_HUMAN
NCBI Gene ID 548594
API
Download Associations
Predicted Functions View KIR3DP1's ARCHS4 Predicted Functions.
Co-expressed Genes View KIR3DP1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View KIR3DP1's ARCHS4 Predicted Functions.

Functional Associations

KIR3DP1 has 200 functional associations with biological entities spanning 5 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for KIR3DP1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CellMarker Gene-Cell Type Associations cell types associated with KIR3DP1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIR3DP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of KIR3DP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
GAD Gene-Disease Associations diseases associated with KIR3DP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with KIR3DP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing KIR3DP1 from the GeneSigDB Published Gene Signatures dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with KIR3DP1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of KIR3DP1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.