{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KIRREL3‐AS2 is an antisense long non‐coding RNA whose functional role is beginning to emerge from studies across diverse biological contexts. On one hand, research into lncRNAs expressed in both gametogenic and cancer tissues has highlighted that many of these RNAs regulate key cellular processes such as telomere biology, chromatin dynamics, modulation of gene expression, and genome organization through pathways including Wnt/β‑catenin and PI3K/AKT/mTOR (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although KIRREL3‐AS2 is not directly discussed in this context, its classification among antisense lncRNAs suggests that it may similarly contribute to the fine‐tuning of gene expression programs shared by gametogenic and tumorigenic processes."}]}, {"type": "t", "text": "\n\n "}, {"type": "p", "children": [{"type": "t", "text": "\n On the other hand, transcriptome profiling in patients with drug‐refractory medial temporal lobe epilepsy (MTLE) has identified KIRREL3‐AS2 as one of a set of deregulated antisense RNAs. In this setting, its altered expression is part of a broader network involving genes central to synaptic transmission, neuronal network modulation, and neuroinflammatory pathways, providing new insights into the genomic underpinnings of epileptogenesis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, while the precise mechanisms of KIRREL3‐AS2 remain to be fully elucidated, evidence from these studies implies that it may play a regulatory role—potentially impacting gene expression and cellular signaling—in both oncogenic/gametogenic processes and the pathophysiology of epilepsy.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ali Dianatpour, Soudeh Ghafouri-Fard "}, {"type": "b", "children": [{"type": "t", "text": "Long Non Coding RNA Expression Intersecting Cancer and Spermatogenesis: A Systematic Review"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.22034/APJCP.2017.18.10.2601"}], "href": "https://doi.org/10.22034/APJCP.2017.18.10.2601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29072050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29072050"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Aparna Banerjee Dixit, Jyotirmoy Banerjee, Arpna Srivastava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2016.04.001"}], "href": "https://doi.org/10.1016/j.ygeno.2016.04.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27094248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27094248"}]}]}]}