{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA KLF3‐AS1 has recently emerged as a multifunctional regulatory molecule with promising therapeutic potential in diverse pathological conditions. In cancer, for example, low expression of KLF3‐AS1 in esophageal squamous cell carcinoma and gastric cancer is associated with enhanced tumor cell proliferation, invasion, migration, epithelial‐to‐mesenchymal transition, and chemoresistance. Upregulation of KLF3‐AS1 in these settings functions as a tumor suppressor by “sponging” specific microRNAs (such as miR‑185‑5p and miR‑223) to upregulate targets like KLF3 and thereby inhibit oncogenic pathways (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of regenerative medicine, KLF3‐AS1 delivered via mesenchymal stem cell (MSC)–derived exosomes has demonstrated efficacy in tissue repair and protection. In osteoarthritis, MSC‐exosomal KLF3‐AS1 improves chondrocyte function by activating the PI3K/Akt/mTOR pathway through interaction with YBX1 and by modulating microRNA axes (such as miR‑206/GIT1) to promote cell proliferation and inhibit apoptosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Similarly, in diabetic cutaneous wound healing, exosomal KLF3‐AS1 derived from bone marrow MSCs supports angiogenesis and tissue repair by targeting the miR‑383/VEGFA axis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while in myocardial infarction, exosomal KLF3‐AS1 protects cardiomyocytes from pyroptosis by sequestering miR‑138‑5p to regulate Sirt1 expression and mitigate ischemia‐reperfusion injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that KLF3‐AS1 acts as a competing endogenous RNA that modulates key signaling pathways by binding to specific miRNAs in various disease contexts. Its ability to attenuate tumor growth, enhance chondrocyte survival, promote angiogenesis, and reduce cardiomyocyte pyroptosis highlights its broad potential as a novel therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun-Qi Liu, Ming Deng, Nan-Nan Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA KLF3-AS1 Suppresses Cell Migration and Invasion in ESCC by Impairing miR-185-5p-Targeted KLF3 Inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2020.01.020"}], "href": "https://doi.org/10.1016/j.omtn.2020.01.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32193151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32193151"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Houxiang Jiang, KaiFeng Hu, Yabing Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA KLF3-AS1 Acts as an Endogenous RNA of miR-223 to Attenuate Gastric Cancer Progression and Chemoresistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.704339"}], "href": "https://doi.org/10.3389/fonc.2021.704339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34745937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34745937"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chuanyang Wen, Lupan Lin, Rui Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.2019411"}], "href": "https://doi.org/10.1080/15384101.2021.2019411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34964696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34964696"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yubao Liu, Lupan Lin, Rui Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2018.1526603"}], "href": "https://doi.org/10.1080/15384101.2018.1526603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30324848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30324848"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yubao Liu, Rui Zou, Zhen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20180675"}], "href": "https://doi.org/10.1042/BCJ20180675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30341166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30341166"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhao-Feng Han, Jun-Hua Cao, Zhong-Yang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal lncRNA KLF3-AS1 derived from bone marrow mesenchymal stem cells stimulates angiogenesis to promote diabetic cutaneous wound healing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes Res Clin Pract (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.diabres.2021.109126"}], "href": "https://doi.org/10.1016/j.diabres.2021.109126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34742784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34742784"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Qing Mao, Xiu-Lin Liang, Chuan-Long Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Res Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13287-019-1522-4"}], "href": "https://doi.org/10.1186/s13287-019-1522-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31847890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31847890"}]}]}]}