{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A recent study applied an innovative computational method, Predicting LncRNA Activity through Integrative Data-driven 'Omics and Heuristics (PLAIDOH), to identify and prioritize functional connections between lymphoma-associated long non-coding RNAs (lncRNAs) and coding genes as well as protein partners."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In this context, the lncRNA KLHL6‐AS1 was highlighted as a novel candidate whose predicted function emerged from integrating transcriptomic profiles, enhancer landscape data, genome architecture, chromatin interactions, and RNA-binding information. PLAIDOH’s analysis suggested that KLHL6‐AS1 may participate in regulatory networks through cis-regulatory mechanisms and by modulating protein interactions, potentially influencing coding gene expression and contributing to lymphoma pathogenesis. Subsequent functional validation via knockdown and knockout experiments in lymphoma cell models corroborated its regulatory role, illustrating KLHL6‐AS1’s involvement in the complex molecular circuitry underlying this disease. This work not only sheds light on the functional implications of KLHL6‐AS1 in lymphoma but also demonstrates the utility of PLAIDOH in uncovering biologically significant lncRNA interactions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sarah C Pyfrom, Hong Luo, Jacqueline E Payton "}, {"type": "b", "children": [{"type": "t", "text": "PLAIDOH: a novel method for functional prediction of long non-coding RNAs identifies cancer-specific LncRNA activities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-019-5497-4"}], "href": "https://doi.org/10.1186/s12864-019-5497-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30767760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30767760"}]}]}]}