{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have unveiled a complex, tissue‐specific role for the long non‐coding antisense RNA KLHL7‑AS1. In a genome‐wide association study of Parkinson’s disease, the risk allele at SNP rs199347 was associated with increased expression of neighboring transcripts—including KLHL7—in brain regions, with parallel findings of decreased KLHL7‑AS1 expression in cortical tissues and differential eQTL effects in immune‐related sites."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, an independent study focusing on endometriosis identified KLHL7‑AS1 among a group of extracellular vesicle–derived lncRNAs that were significantly upregulated in the plasma of affected patients, suggesting its potential utility as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings indicate that KLHL7‑AS1 may participate in distinct regulatory networks—potentially contributing to both neurodegenerative and gynecologic disease processes—thereby warranting further investigation into its biological function and clinical relevance.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Megha N Murthy, Cornelis Blauwendraat, Sebastian Guelfi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-017-0514-8"}], "href": "https://doi.org/10.1007/s10048-017-0514-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28391543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28391543"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shan Shan, Yeping Yang, Jilan Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular vesicle-derived long non-coding RNA as circulating biomarkers for endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biomed Online (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.rbmo.2021.11.019"}], "href": "https://doi.org/10.1016/j.rbmo.2021.11.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35341703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35341703"}]}]}]}