{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent transcriptomic analyses in MCF7 cells treated with the topoisomerase II inhibitor etoposide have revealed that the long non‐coding RNA KMT2E‐AS1 is part of a specific transcriptional response activated upon induction of double‐strand breaks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although etoposide treatment does not globally affect mRNA abundance, specific genes, including KMT2E‐AS1, exhibit altered expression, suggesting that KMT2E‐AS1 may contribute to the coordination between the DNA damage response (DDR) and transcription processes. This regulation likely helps to fine‐tune checkpoint activation and repair mechanisms, thereby integrating lesion repair with transcriptional control. Further studies are warranted to delineate the precise mechanistic role of KMT2E‐AS1 within the DDR network.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fengxiang Wei, Peng Hao, Xiangzhong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.24517"}], "href": "https://doi.org/10.18632/oncotarget.24517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29844877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29844877"}]}]}]}