{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCandidaemia, a life‐threatening bloodstream infection with mortality rates reaching 40%, has been linked to host genetic variation in immune genes. Recent studies have identified single‐nucleotide polymorphisms (SNPs) not only in established immune loci such as CD58 and TAGAP but also within the LCE4A-C1orf68 region. Within this region, KPLCE is hypothesized to play a role in antifungal host defence. Although the precise function of KPLCE remains to be fully delineated, its genetic association with candidaemia suggests that it may participate in regulating immune responses—possibly by influencing epithelial barrier integrity or modulating immune cell activation—thereby affecting the host’s ability to clear invasive fungal pathogens."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In the largest cohort study to date of European candidaemia patients, carriage of multiple risk alleles, including those in the LCE4A-C1orf68 locus where KPLCE is located, was associated with a markedly elevated risk (up to 19.4-fold) of developing the infection. These findings underscore the potential of KPLCE as part of a complex network of immune mediators that determine susceptibility to candidaemia and highlight its promise as a target for adjunctive immunotherapeutic strategies aimed at improving antifungal defence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vinod Kumar, Shih-Chin Cheng, Melissa D Johnson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms5675"}], "href": "https://doi.org/10.1038/ncomms5675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25197941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25197941"}]}]}]}