{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KRBOX1-AS1 is a long noncoding RNA that appears to be involved in the modulation of key molecular pathways across distinct pathological conditions. In the context of COVID-19, dysregulation of host factors—among which KRBOX1-AS1 may play a role—could influence the expression or function of proteins essential for viral entry, such as angiotensin‐converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Meanwhile, analyses in patients with valvular atrial fibrillation have identified a panel of differentially expressed long noncoding RNAs in the left atrium, suggesting that KRBOX1-AS1 may contribute to atrial remodeling, altered immune cell infiltration, and epigenetic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings indicate that KRBOX1-AS1 might serve as a regulatory modulator in both viral infection and cardiac pathology, potentially offering a novel target for diagnostic and therapeutic strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Soudabeh Sabetian, Isabella Castiglioni, Bahia Namavar Jahromi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In Silico Identification of miRNA-lncRNA Interactions in Male Reproductive Disorder Associated with COVID-19 Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10061480"}], "href": "https://doi.org/10.3390/cells10061480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34204705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34204705"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jiafeng Wu, Huiming Deng, Qianghua Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of Differential Immunocyte Infiltration and Potential ceRNA Networks Involved in the Development of Atrial Fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8021208"}], "href": "https://doi.org/10.1155/2020/8021208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33015181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33015181"}]}]}]}