{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KRTAP10-5 is a member of the high‐sulfur keratin‐associated protein family that is expressed exclusively in hair follicle cells and contributes to the structural integrity of the hair fiber. In studies of androgenetic alopecia, topical treatment with minoxidil was shown to stimulate the expression of hair keratin‐associated genes, which is associated with the reversal of hair miniaturization and improved hair growth in both the frontal and vertex regions of the scalp."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Detailed genomic analyses have further characterized clusters of hair‐specific KAP genes—including those closely related in structure and function to KRTAP10-5—that reside within a defined genomic region and display a unique transcriptional mechanism, evidenced by their intronless transcripts and their co‐localization within the introns of the TSPEAR gene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although other studies have focused on dissecting complex cellular networks such as ciliary signaling and its links to diverse genetic diseases"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", the function of KRTAP10-5 is more directly tied to the formation and resilience of hair fibers. Together, these findings support a role for KRTAP10-5 in hair fiber assembly, where its regulated expression may be critical for maintaining hair shaft strength and quality.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "P Mirmirani, M Consolo, P Oyetakin-White, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Similar response patterns to topical minoxidil foam 5% in frontal and vertex scalp of men with androgenetic alopecia: a microarray analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Dermatol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bjd.13399"}], "href": "https://doi.org/10.1111/bjd.13399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25204361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25204361"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kazunori Shibuya, Izumi Obayashi, Shuichi Asakawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2003.09.024"}], "href": "https://doi.org/10.1016/j.ygeno.2003.09.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15028290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15028290"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An organelle-specific protein landscape identifies novel diseases and molecular mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11491"}], "href": "https://doi.org/10.1038/ncomms11491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27173435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27173435"}]}]}]}