{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KRTAP13-3 is one of the keratin‐associated protein genes that, like other members of its family, is believed to contribute to the structure and physical integrity of keratin‐rich fibers such as wool. In wool‐producing species, the diverse KAPs—by cross‐linking with keratin intermediate filaments—are responsible for key fiber properties including strength and resilience."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In addition to its presumed structural role in fiber formation, KRTAP13-3 has also been identified in an epigenetic senescence signature, where its methylation level at a specific CpG site is used—together with markers from several other genes—to accurately predict the replicative aging of mesenchymal stromal cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " This dual relevance underscores not only the importance of KRTAP13-3 in establishing fiber characteristics valuable to industries such as wool production but also its potential utility as a biomarker for cellular aging in regenerative medicine and quality control of cell-based therapies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wendy J M Smith, Yutao Li, Aaron Ingham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genomics-informed, SNP association study reveals FBLN1 and FABP4 as contributing to resistance to fleece rot in Australian Merino sheep."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Vet Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1746-6148-6-27"}], "href": "https://doi.org/10.1186/1746-6148-6-27"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20500888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20500888"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hua Gong, Huitong Zhou, Rachel H J Forrest, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wool Keratin-Associated Protein Genes in Sheep-A Review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes7060024"}], "href": "https://doi.org/10.3390/genes7060024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27240405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27240405"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lingrong Bai, Jing Wang, Huitong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Ovine KRTAP28-1 and Its Association with Wool Fibre Diameter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Animals (Basel) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ani9040142"}], "href": "https://doi.org/10.3390/ani9040142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30987059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30987059"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Anne Schellenberg, Sébastien Mauen, Carmen Mareike Koch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Res Notes (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1756-0500-7-254"}], "href": "https://doi.org/10.1186/1756-0500-7-254"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24755407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24755407"}]}]}]}