{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KRTAP27-1 is a member of the keratin‐associated protein (KAP) gene family that is thought to contribute to the structural integrity of hair by facilitating the bundling of keratin intermediate filaments. Although its precise role in human hair follicles remains to be fully elucidated—especially when compared with other family members that show robust expression in differentiated hair components (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "—genomic studies have identified variants in KRTAP27-1 that may have implications beyond hair biology. In particular, one study detected a germline variant (rs2244485) in KRTAP27-1 that was potentially associated with a gastric cancer pedigree and a less strictly defined form of hereditary colorectal cancer (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In a related line of research, investigations in goats confirmed the identification of a caprine homolog of KAP27-1 and associated its variation with cashmere fiber traits, underscoring a conserved structural role in hair or fiber formation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additionally, broader proteomic analyses of cellular organelles have provided context for protein complex formation and trafficking in highly specialized structures such as cilia, illustrating the power of organelle‐specific approaches to elucidate protein function, although KRTAP27-1 per se was not a central focus of this work (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M A Rogers, L Langbein, S Praetzel-Wunder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization and expression analysis of the hair keratin associated protein KAP26.1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Dermatol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2133.2008.08743.x"}], "href": "https://doi.org/10.1111/j.1365-2133.2008.08743.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18647308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18647308"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jin Cheon Kim, Jong Hwan Kim, Ye Jin Ha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of genomic pathogenesis according to the revised Bethesda guidelines and additional criteria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-020-03391-8"}], "href": "https://doi.org/10.1007/s00432-020-03391-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32960359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32960359"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mengli Zhao, Huitong Zhou, Yuzhu Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variation in the Caprine Keratin-Associated Protein 27-1 Gene is Associated with Cashmere Fiber Diameter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes11080934"}], "href": "https://doi.org/10.3390/genes11080934"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32823629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32823629"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An organelle-specific protein landscape identifies novel diseases and molecular mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11491"}], "href": "https://doi.org/10.1038/ncomms11491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27173435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27173435"}]}]}]}