KRTAP29-1 Gene

HGNC Family Keratin associated proteins (KRTAP)
Name keratin associated protein 29-1
Description Predicted to enable structural molecule activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent systems‐based analyses of the ciliary proteome have revealed an unexpectedly complex network of protein interactions that connect vesicle transport, cytoskeletal organization, signaling, and ubiquitination to ciliary structure and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Within this comprehensive landscape—constructed from 217 tagged human ciliary proteins and encompassing 1,319 proteins—KRTAP29-1 was identified. Although keratin‐associated proteins are classically known for their roles in hair shaft formation and the organization of keratin filaments, the detection of KRTAP29-1 in this ciliary network suggests that it may have an additional, context‐dependent function within the cilium. Its association with sub‐complexes that interface with elements of the cytoskeleton and vesicle transport implies that KRTAP29-1 could contribute to the structural integrity or the regulatory dynamics of ciliary assembly and signaling. These findings pave the way for future studies to determine whether KRTAP29-1 serves as an adaptor or stabilizer that integrates classical keratin dynamics with novel aspects of ciliary biology, potentially offering insights into mechanisms underlying ciliopathies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An organelle-specific protein landscape identifies novel diseases and molecular mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11491"}], "href": "https://doi.org/10.1038/ncomms11491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27173435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27173435"}]}]}]}
Synonyms KAP29.2
Proteins KR291_HUMAN
NCBI Gene ID 100533177
API
Download Associations
Predicted Functions View KRTAP29-1's ARCHS4 Predicted Functions.
Co-expressed Genes View KRTAP29-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View KRTAP29-1's ARCHS4 Predicted Functions.

Functional Associations

KRTAP29-1 has 318 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 20 datasets.

Click the + buttons to view associations for KRTAP29-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of KRTAP29-1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing KRTAP29-1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with KRTAP29-1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of KRTAP29-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with KRTAP29-1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by KRTAP29-1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with KRTAP29-1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing KRTAP29-1 protein from the curated GO Cellular Component Annotations 2015 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of KRTAP29-1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of KRTAP29-1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for KRTAP29-1 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of KRTAP29-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of KRTAP29-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of KRTAP29-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of KRTAP29-1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Reactome Pathways 2024 pathways involving KRTAP29-1 protein from the Reactome Pathways 2024 dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of KRTAP29-1 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of KRTAP29-1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of KRTAP29-1 gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with KRTAP29-1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.