{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KRTAP5‑AS1 is a long non‑coding RNA that contributes to tumorigenesis through its function as a competing endogenous RNA (ceRNA). In gastric cancer, KRTAP5‑AS1 sequesters specific microRNAs that would otherwise suppress the expression of Claudin‑4, thereby indirectly enhancing Claudin‑4 levels and promoting malignant behaviors such as increased cell proliferation, invasion, and epithelial‑to‑mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n Furthermore, evidence from hepatitis B virus‑related hepatocellular carcinoma indicates that KRTAP5‑AS1 is part of an eight‑lncRNA prognostic signature; within this ceRNA network, it is co‑expressed with other key transcripts involved in cell cycle regulation, suggesting that its aberrant expression may contribute to tumor progression in a broader context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight KRTAP5‑AS1 as a multifaceted regulator in cancer, with its ceRNA activity influencing both the expression of key oncogenic proteins and the modulation of cell cycle–related pathways. Thus, KRTAP5‑AS1 holds promise as a potential biomarker and therapeutic target in multiple cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yong-Xi Song, Jing-Xu Sun, Jun-Hua Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-00304-1"}], "href": "https://doi.org/10.1038/s41467-017-00304-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28819095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28819095"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaonan Zhao, Zhenzi Bai, Chenghua Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a Novel Eight-lncRNA Prognostic Signature for HBV-HCC and Analysis of Their Functions Based on Coexpression and ceRNA Networks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8765461"}], "href": "https://doi.org/10.1155/2020/8765461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32382578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32382578"}]}]}]}