{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent large‐scale multi‐omics studies have provided new insights into KRTAP9‑8, a member of the keratin‐associated protein family encoded on chromosome 17. Analyses of thousands of transcriptional signatures have revealed that KRTAP9‑8 is part of highly co‐regulated gene networks, supporting a role in specialized structural functions (1,4). Complementary in silico and semantic network approaches have integrated gene expression with genetic variation data, suggesting that KRTAP9‑8, along with other keratin‐associated proteins, may contribute to tissue-specific properties and could underlie, in part, genotypic differences observed between populations (2,4). Moreover, the targeted proteomics strategies used in organelle‐focused studies have confirmed the existence of previously “missing” proteins—including several keratin‐associated proteins—to form integral components of complexes involved in cellular integrity, supporting the view that KRTAP9‑8 is not only structurally important but may also participate in broader protein–protein interaction networks (3,4). Overall, the convergence of transcriptomic, proteomic, and semantic modeling data emphasizes KRTAP9‑8’s contribution to the structural and regulatory frameworks of specialized epithelial tissues."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fabrice Lopez, Julien Textoris, Aurélie Bergon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TranscriptomeBrowser: a powerful and flexible toolbox to explore productively the transcriptional landscape of the Gene Expression Omnibus database."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0004001"}], "href": "https://doi.org/10.1371/journal.pone.0004001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19104654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19104654"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hyoyoung Kim, Won Gi Yoo, Junhyung Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semantic Modeling for SNPs Associated with Ethnic Disparities in HapMap Samples."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics Inform (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5808/GI.2014.12.1.35"}], "href": "https://doi.org/10.5808/GI.2014.12.1.35"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24748859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24748859"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An organelle-specific protein landscape identifies novel diseases and molecular mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11491"}], "href": "https://doi.org/10.1038/ncomms11491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27173435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27173435"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Omer Siddiqui, Hongjiu Zhang, Yuanfang Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromosome 17 Missing Proteins: Recent Progress and Future Directions as Part of the neXt-MP50 Challenge."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.8b00442"}], "href": "https://doi.org/10.1021/acs.jproteome.8b00442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30280577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30280577"}]}]}]}